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Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease

Glucocerebrosidase (GBA1) gene mutations increase the risk of Parkinson disease (PD). While the cellular mechanisms associating GBA1 mutations and PD are unknown, loss of the glucocerebrosidase enzyme (GCase) activity, inhibition of autophagy and increased α-synuclein levels have been implicated. He...

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Detalles Bibliográficos
Autores principales:	Magalhaes, Joana, Gegg, Matthew E., Migdalska-Richards, Anna, Doherty, Mary K., Whitfield, Phillip D., Schapira, Anthony H.V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5179940/ https://www.ncbi.nlm.nih.gov/pubmed/27378698 http://dx.doi.org/10.1093/hmg/ddw185

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