Disrupted mitochondrial function in the Opa3(L122P) mouse model for Costeff Syndrome impairs skeletal integrity

Mitochondrial dysfunction connects metabolic disturbance with numerous pathologies, but the significance of mitochondrial activity in bone remains unclear. We have, therefore, characterized the skeletal phenotype in the Opa3(L122P) mouse model for Costeff syndrome, in which a missense mutation of th...

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Detalles Bibliográficos
Autores principales: Navein, Alice E., Cooke, Esther J., Davies, Jennifer R., Smith, Terence G., Wells, Lois H. M., Ohazama, Atsushi, Healy, Christopher, Sharpe, Paul T., Evans, Sam L., Evans, Bronwen A. J., Votruba, Marcela, Wells, Timothy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181626/
https://www.ncbi.nlm.nih.gov/pubmed/27106103
http://dx.doi.org/10.1093/hmg/ddw107

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