Cargando…

Structural and molecular myelination deficits occur prior to neuronal loss in the YAC128 and BACHD models of Huntington disease

White matter (WM) atrophy is a significant feature of Huntington disease (HD), although its aetiology and early pathological manifestations remain poorly defined. In this study, we aimed to characterize WM-related features in the transgenic YAC128 and BACHD models of HD. Using diffusion tensor magne...

Descripción completa

Detalles Bibliográficos
Autores principales:	Teo, Roy Tang Yi, Hong, Xin, Yu-Taeger, Libo, Huang, Yihui, Tan, Liang Juin, Xie, Yuanyun, To, Xuan Vinh, Guo, Ling, Rajendran, Reshmi, Novati, Arianna, Calaminus, Carsten, Riess, Olaf, Hayden, Michael R., Nguyen, Huu P., Chuang, Kai-Hsiang, Pouladi, Mahmoud A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181633/ https://www.ncbi.nlm.nih.gov/pubmed/27126634 http://dx.doi.org/10.1093/hmg/ddw122

Ejemplares similares

Laquinimod rescues striatal, cortical and white matter pathology and results in modest behavioural improvements in the YAC128 model of Huntington disease
por: Garcia-Miralles, Marta, et al.
Publicado: (2016)

Environment-dependent striatal gene expression in the BACHD rat model for Huntington disease
por: Novati, Arianna, et al.
Publicado: (2018)

Sexual behavior and testis morphology in the BACHD rat model
por: Novati, Arianna, et al.
Publicado: (2018)

Differential Cellular Balance of Olfactory and Vomeronasal Epithelia in a Transgenic BACHD Rat Model of Huntington’s Disease
por: Krysewski, Lina-Marielle, et al.
Publicado: (2022)

Antidepressant Effects of Probucol on Early-Symptomatic YAC128 Transgenic Mice for Huntington's Disease
por: de Paula Nascimento-Castro, Cristine, et al.
Publicado: (2018)

Temporal Characterization of Behavioral and Hippocampal Dysfunction in the YAC128 Mouse Model of Huntington’s Disease
por: de Paula Nascimento-Castro, Cristine, et al.
Publicado: (2022)

Reduced Motivation in the BACHD Rat Model of Huntington Disease Is Dependent on the Choice of Food Deprivation Strategy
por: Jansson, Erik Karl Håkan, et al.
Publicado: (2014)

Mice lacking caspase-2 are protected from behavioral changes, but not pathology, in the YAC128 model of Huntington disease
por: Carroll, Jeffrey B, et al.
Publicado: (2011)

Efficacy of Fumaric Acid Esters in the R6/2 and YAC128 Models of Huntington's Disease
por: Ellrichmann, Gisa, et al.
Publicado: (2011)

Transplantation of patient-derived adipose stem cells in YAC128 Huntington's disease transgenic mice
por: Im, Wooseok, et al.
Publicado: (2010)

Neonatal Iron Supplementation Induces Striatal Atrophy in Female YAC128 Huntington’s Disease Mice
por: Berggren, Kiersten L., et al.
Publicado: (2016)

Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease
por: Bečanović, Kristina, et al.
Publicado: (2021)

Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice
por: Plácido, Evelini, et al.
Publicado: (2023)

The Alteration of Emotion Regulation Precedes the Deficits in Interval Timing in the BACHD Rat Model for Huntington Disease
por: Garces, Daniel, et al.
Publicado: (2018)

Altering cortical input unmasks synaptic phenotypes in the YAC128 cortico-striatal co-culture model of Huntington disease
por: Schmidt, Mandi E., et al.
Publicado: (2018)

Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse
por: Kusko, Rebecca, et al.
Publicado: (2018)

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease
por: Van Raamsdonk, Jeremy M, et al.
Publicado: (2006)

Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease
por: Clemensson, Erik Karl Håkan, et al.
Publicado: (2017)

Author Correction: Age-related mitochondrial alterations in brain and skeletal muscle of the YAC128 model of Huntington disease
por: Bečanović, Kristina, et al.
Publicado: (2021)

The BACHD Rat Model of Huntington Disease Shows Signs of Fronto-Striatal Dysfunction in Two Operant Conditioning Tests of Short-Term Memory
por: Clemensson, Erik Karl Håkan, et al.
Publicado: (2017)

Evidences for Mutant Huntingtin Inducing Musculoskeletal and Brain Growth Impairments via Disturbing Testosterone Biosynthesis in Male Huntington Disease Animals
por: Yu-Taeger, Libo, et al.
Publicado: (2022)

Neural stem cells derived from the developing forebrain of YAC128 mice exhibit pathological features of Huntington’s disease
por: Li, Endan, et al.
Publicado: (2020)

Correction: Further investigation of phenotypes and confounding factors of progressive ratio performance and feeding behavior in the BACHD rat model of Huntington disease
por: Clemensson, Erik Karl Håkan, et al.
Publicado: (2019)

Reversal Learning and Associative Memory Impairments in a BACHD Rat Model for Huntington Disease
por: Abada, Yah-se K., et al.
Publicado: (2013)

Cardiac Dysfunction in the BACHD Mouse Model of Huntington’s Disease
por: Schroeder, Analyne M., et al.
Publicado: (2016)

DAPK1 Promotes Extrasynaptic GluN2B Phosphorylation and Striatal Spine Instability in the YAC128 Mouse Model of Huntington Disease
por: Schmidt, Mandi E., et al.
Publicado: (2020)

A CAG repeat-targeting artificial miRNA lowers the mutant huntingtin level in the YAC128 model of Huntington's disease
por: Kotowska-Zimmer, Anna, et al.
Publicado: (2022)

Baroreceptor reflex dysfunction in the BACHD mouse model of Huntington’s disease.
por: Schroeder, Analyne M., et al.
Publicado: (2011)

Differential Synaptic and Extrasynaptic Glutamate-Receptor Alterations in Striatal Medium-Sized Spiny Neurons of Aged YAC128 Huntington’s Disease Mice
por: Botelho, Eliã P., et al.
Publicado: (2014)

Correction: Differential Synaptic and Extrasynaptic Glutamate-Receptor Alterations in Striatal Medium-Sized Spiny Neurons of Aged YAC128 Huntington's Disease Mice
Publicado: (2017)

Sex Differences in Circadian Dysfunction in the BACHD Mouse Model of Huntington’s Disease
por: Kuljis, Dika A., et al.
Publicado: (2016)

Sex Differences in Sleep Phenotypes in the BACHD Mouse Model of Huntington’s Disease
por: Chiem, Emily, et al.
Publicado: (2023)

The BACHD Rat Model of Huntington Disease Shows Specific Deficits in a Test Battery of Motor Function
por: Manfré, Giuseppe, et al.
Publicado: (2017)

In vivo Dopamine Efflux is Decreased in Striatum of both Fragment (R6/2) and Full-Length (YAC128) Transgenic Mouse Models of Huntington's Disease
por: Callahan, Joshua W., et al.
Publicado: (2011)

In Vivo Roles of a Patient-Derived Induced Pluripotent Stem Cell Line (HD72-iPSC) in the YAC128 Model of Huntington’s Disease
por: Jeon, Iksoo, et al.
Publicado: (2014)

Solid Lipid Curcumin Particles Protect Medium Spiny Neuronal Morphology, and Reduce Learning and Memory Deficits in the YAC128 Mouse Model of Huntington’s Disease
por: Gharaibeh, Abeer, et al.
Publicado: (2020)

BACHD Mice Recapitulate the Striatal Parvalbuminergic Interneuron Loss Found in Huntington’s Disease
por: Rallapalle, Vyshnavi, et al.
Publicado: (2021)

Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington’s disease are not reflected in mutant Huntingtin inclusion prevalence
por: Bayram-Weston, Zubeyde, et al.
Publicado: (2015)

Assessment of Motor Function, Sensory Motor Gating and Recognition Memory in a Novel BACHD Transgenic Rat Model for Huntington Disease
por: Abada, Yah-se K., et al.
Publicado: (2013)

Effects of mutant huntingtin inactivation on Huntington disease‐related behaviours in the BACHD mouse model
por: Cheong, Rachel Y., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_03fhk7vimapua9fou2pn2qn2n4