Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease

In this review, we outline the role of the cholinergic system in Huntington’s disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem human brains and animal models of Huntington’s...

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Detalles Bibliográficos
Autores principales: D’Souza, Gary X., Waldvogel, Henry J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181681/
https://www.ncbi.nlm.nih.gov/pubmed/27983560
http://dx.doi.org/10.3233/JHD-160200
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author D’Souza, Gary X.
Waldvogel, Henry J.
author_facet D’Souza, Gary X.
Waldvogel, Henry J.
author_sort D’Souza, Gary X.
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description In this review, we outline the role of the cholinergic system in Huntington’s disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem human brains and animal models of Huntington’s disease. We postulate how the dysfunctional cholinergic system can be targeted to develop novel therapies for Huntington’s disease, and discuss the beneficial effects of cholinergic therapies in pre-clinical and clinical studies.
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spelling pubmed-51816812016-12-27 Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease D’Souza, Gary X. Waldvogel, Henry J. J Huntingtons Dis Review In this review, we outline the role of the cholinergic system in Huntington’s disease, and briefly describe the dysfunction of cholinergic transmission, cholinergic neurons, cholinergic receptors and cholinergic survival factors observed in post-mortem human brains and animal models of Huntington’s disease. We postulate how the dysfunctional cholinergic system can be targeted to develop novel therapies for Huntington’s disease, and discuss the beneficial effects of cholinergic therapies in pre-clinical and clinical studies. IOS Press 2016-12-15 /pmc/articles/PMC5181681/ /pubmed/27983560 http://dx.doi.org/10.3233/JHD-160200 Text en IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
D’Souza, Gary X.
Waldvogel, Henry J.
Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease
title Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease
title_full Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease
title_fullStr Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease
title_full_unstemmed Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease
title_short Targeting the Cholinergic System to Develop a Novel Therapy for Huntington’s Disease
title_sort targeting the cholinergic system to develop a novel therapy for huntington’s disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181681/
https://www.ncbi.nlm.nih.gov/pubmed/27983560
http://dx.doi.org/10.3233/JHD-160200
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