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A small protein inhibits proliferating cell nuclear antigen by breaking the DNA clamp

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Proliferating cell nuclear antigen (PCNA) forms a trimeric ring that encircles duplex DNA and acts as an anchor for a number of proteins involved in DNA metabolic processes. PCNA has two structurally similar domains (I and II) linked by a long loop (inter-domain connector loop, IDCL) on the outside...

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Detalles Bibliográficos
Autores principales:	Altieri, Amanda S., Ladner, Jane E., Li, Zhuo, Robinson, Howard, Sallman, Zahur F., Marino, John P., Kelman, Zvi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181682/ https://www.ncbi.nlm.nih.gov/pubmed/27141962 http://dx.doi.org/10.1093/nar/gkw351

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