Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells

We characterized the acute B cell response in adults with cholera by analyzing the repertoire, specificity, and functional characteristics of 138 monoclonal antibodies (MAbs) generated from single-cell-sorted plasmablasts. We found that the cholera-induced responses were characterized by high levels...

Descripción completa

Detalles Bibliográficos
Autores principales: Kauffman, Robert C., Bhuiyan, Taufiqur R., Nakajima, Rie, Mayo-Smith, Leslie M., Rashu, Rasheduzzaman, Hoq, Mohammad Rubel, Chowdhury, Fahima, Khan, Ashraful Islam, Rahman, Atiqur, Bhaumik, Siddhartha K., Harris, Levelle, O'Neal, Justin T., Trost, Jessica F., Alam, Nur Haq, Jasinskas, Algis, Dotsey, Emmanuel, Kelly, Meagan, Charles, Richelle C., Xu, Peng, Kováč, Pavol, Calderwood, Stephen B., Ryan, Edward T., Felgner, Phillip L., Qadri, Firdausi, Wrammert, Jens, Harris, Jason B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181778/
https://www.ncbi.nlm.nih.gov/pubmed/27999163
http://dx.doi.org/10.1128/mBio.02021-16

Ejemplares similares

Ejemplares similares