Cargando…

Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period

Currently, there are few guidelines for the use of vitamin K1 in the maintenance treatment of long-acting anticoagulant rodenticide (LAAR) poisonings. We explored factors in the treatment of LAAR poisoning during the maintenance period in order to suggest feasible treatment models. Data from 24 case...

Descripción completa

Detalles Bibliográficos
Autores principales: Long, Jianhai, Peng, Xiaobo, Luo, Yuan, Sun, Yawei, Lin, Guodong, Wang, Yongan, Qiu, Zewu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181810/
https://www.ncbi.nlm.nih.gov/pubmed/28002326
http://dx.doi.org/10.1097/MD.0000000000005461
_version_ 1782485772093358080
author Long, Jianhai
Peng, Xiaobo
Luo, Yuan
Sun, Yawei
Lin, Guodong
Wang, Yongan
Qiu, Zewu
author_facet Long, Jianhai
Peng, Xiaobo
Luo, Yuan
Sun, Yawei
Lin, Guodong
Wang, Yongan
Qiu, Zewu
author_sort Long, Jianhai
collection PubMed
description Currently, there are few guidelines for the use of vitamin K1 in the maintenance treatment of long-acting anticoagulant rodenticide (LAAR) poisonings. We explored factors in the treatment of LAAR poisoning during the maintenance period in order to suggest feasible treatment models. Data from 24 cases of anticoagulant rodenticide poisoning in our hospital were collected from January 2013 to May 2016. The patients’ sex, age, coagulation function, total time from poisoning to treatment with vitamin K1 (prehospital time), vitamin K1 sustained treatment time (VKSTT), anticoagulant rodenticide category, and specific poison dosage were collected. Multivariate analysis was used to evaluate the correlation between vitamin K1 dosage and other factors during the maintenance period. Only VKSTT (partial regression coefficient −1.133, 0.59, P = 0.035) had an obvious influence on the therapeutic dose of vitamin K1 required during the maintenance period. After an initial pulse therapy, the bleeding and coagulation functions were stabilized, and the patients were subsequently treated with vitamin K1 during the maintenance period. Over time, the maintenance dose of vitamin K1 (10–120 mg/d, intravenous drip) was gradually decreased and was not related to toxicant concentration.
format Online
Article
Text
id pubmed-5181810
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Wolters Kluwer Health
record_format MEDLINE/PubMed
spelling pubmed-51818102016-12-28 Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period Long, Jianhai Peng, Xiaobo Luo, Yuan Sun, Yawei Lin, Guodong Wang, Yongan Qiu, Zewu Medicine (Baltimore) 7200 Currently, there are few guidelines for the use of vitamin K1 in the maintenance treatment of long-acting anticoagulant rodenticide (LAAR) poisonings. We explored factors in the treatment of LAAR poisoning during the maintenance period in order to suggest feasible treatment models. Data from 24 cases of anticoagulant rodenticide poisoning in our hospital were collected from January 2013 to May 2016. The patients’ sex, age, coagulation function, total time from poisoning to treatment with vitamin K1 (prehospital time), vitamin K1 sustained treatment time (VKSTT), anticoagulant rodenticide category, and specific poison dosage were collected. Multivariate analysis was used to evaluate the correlation between vitamin K1 dosage and other factors during the maintenance period. Only VKSTT (partial regression coefficient −1.133, 0.59, P = 0.035) had an obvious influence on the therapeutic dose of vitamin K1 required during the maintenance period. After an initial pulse therapy, the bleeding and coagulation functions were stabilized, and the patients were subsequently treated with vitamin K1 during the maintenance period. Over time, the maintenance dose of vitamin K1 (10–120 mg/d, intravenous drip) was gradually decreased and was not related to toxicant concentration. Wolters Kluwer Health 2016-12-23 /pmc/articles/PMC5181810/ /pubmed/28002326 http://dx.doi.org/10.1097/MD.0000000000005461 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 7200
Long, Jianhai
Peng, Xiaobo
Luo, Yuan
Sun, Yawei
Lin, Guodong
Wang, Yongan
Qiu, Zewu
Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period
title Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period
title_full Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period
title_fullStr Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period
title_full_unstemmed Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period
title_short Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period
title_sort treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin k1 during the maintenance period
topic 7200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181810/
https://www.ncbi.nlm.nih.gov/pubmed/28002326
http://dx.doi.org/10.1097/MD.0000000000005461
work_keys_str_mv AT longjianhai treatmentofalongactinganticoagulantrodenticidepoisoningcohortwithvitamink1duringthemaintenanceperiod
AT pengxiaobo treatmentofalongactinganticoagulantrodenticidepoisoningcohortwithvitamink1duringthemaintenanceperiod
AT luoyuan treatmentofalongactinganticoagulantrodenticidepoisoningcohortwithvitamink1duringthemaintenanceperiod
AT sunyawei treatmentofalongactinganticoagulantrodenticidepoisoningcohortwithvitamink1duringthemaintenanceperiod
AT linguodong treatmentofalongactinganticoagulantrodenticidepoisoningcohortwithvitamink1duringthemaintenanceperiod
AT wangyongan treatmentofalongactinganticoagulantrodenticidepoisoningcohortwithvitamink1duringthemaintenanceperiod
AT qiuzewu treatmentofalongactinganticoagulantrodenticidepoisoningcohortwithvitamink1duringthemaintenanceperiod