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Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period
Currently, there are few guidelines for the use of vitamin K1 in the maintenance treatment of long-acting anticoagulant rodenticide (LAAR) poisonings. We explored factors in the treatment of LAAR poisoning during the maintenance period in order to suggest feasible treatment models. Data from 24 case...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181810/ https://www.ncbi.nlm.nih.gov/pubmed/28002326 http://dx.doi.org/10.1097/MD.0000000000005461 |
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author | Long, Jianhai Peng, Xiaobo Luo, Yuan Sun, Yawei Lin, Guodong Wang, Yongan Qiu, Zewu |
author_facet | Long, Jianhai Peng, Xiaobo Luo, Yuan Sun, Yawei Lin, Guodong Wang, Yongan Qiu, Zewu |
author_sort | Long, Jianhai |
collection | PubMed |
description | Currently, there are few guidelines for the use of vitamin K1 in the maintenance treatment of long-acting anticoagulant rodenticide (LAAR) poisonings. We explored factors in the treatment of LAAR poisoning during the maintenance period in order to suggest feasible treatment models. Data from 24 cases of anticoagulant rodenticide poisoning in our hospital were collected from January 2013 to May 2016. The patients’ sex, age, coagulation function, total time from poisoning to treatment with vitamin K1 (prehospital time), vitamin K1 sustained treatment time (VKSTT), anticoagulant rodenticide category, and specific poison dosage were collected. Multivariate analysis was used to evaluate the correlation between vitamin K1 dosage and other factors during the maintenance period. Only VKSTT (partial regression coefficient −1.133, 0.59, P = 0.035) had an obvious influence on the therapeutic dose of vitamin K1 required during the maintenance period. After an initial pulse therapy, the bleeding and coagulation functions were stabilized, and the patients were subsequently treated with vitamin K1 during the maintenance period. Over time, the maintenance dose of vitamin K1 (10–120 mg/d, intravenous drip) was gradually decreased and was not related to toxicant concentration. |
format | Online Article Text |
id | pubmed-5181810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-51818102016-12-28 Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period Long, Jianhai Peng, Xiaobo Luo, Yuan Sun, Yawei Lin, Guodong Wang, Yongan Qiu, Zewu Medicine (Baltimore) 7200 Currently, there are few guidelines for the use of vitamin K1 in the maintenance treatment of long-acting anticoagulant rodenticide (LAAR) poisonings. We explored factors in the treatment of LAAR poisoning during the maintenance period in order to suggest feasible treatment models. Data from 24 cases of anticoagulant rodenticide poisoning in our hospital were collected from January 2013 to May 2016. The patients’ sex, age, coagulation function, total time from poisoning to treatment with vitamin K1 (prehospital time), vitamin K1 sustained treatment time (VKSTT), anticoagulant rodenticide category, and specific poison dosage were collected. Multivariate analysis was used to evaluate the correlation between vitamin K1 dosage and other factors during the maintenance period. Only VKSTT (partial regression coefficient −1.133, 0.59, P = 0.035) had an obvious influence on the therapeutic dose of vitamin K1 required during the maintenance period. After an initial pulse therapy, the bleeding and coagulation functions were stabilized, and the patients were subsequently treated with vitamin K1 during the maintenance period. Over time, the maintenance dose of vitamin K1 (10–120 mg/d, intravenous drip) was gradually decreased and was not related to toxicant concentration. Wolters Kluwer Health 2016-12-23 /pmc/articles/PMC5181810/ /pubmed/28002326 http://dx.doi.org/10.1097/MD.0000000000005461 Text en Copyright © 2016 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 7200 Long, Jianhai Peng, Xiaobo Luo, Yuan Sun, Yawei Lin, Guodong Wang, Yongan Qiu, Zewu Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period |
title | Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period |
title_full | Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period |
title_fullStr | Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period |
title_full_unstemmed | Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period |
title_short | Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period |
title_sort | treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin k1 during the maintenance period |
topic | 7200 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5181810/ https://www.ncbi.nlm.nih.gov/pubmed/28002326 http://dx.doi.org/10.1097/MD.0000000000005461 |
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