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Domain-specific cognitive impairment in patients with COPD and control subjects

Impaired cognitive function is increasingly recognized in COPD. Yet, the prevalence of cognitive impairment in specific cognitive domains in COPD has been poorly studied. The aim of this cross-sectional observational study was to compare the prevalence of domain-specific cognitive impairment between...

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Autores principales: Cleutjens, Fiona AHM, Franssen, Frits ME, Spruit, Martijn A, Vanfleteren, Lowie EGW, Gijsen, Candy, Dijkstra, Jeanette B, Ponds, Rudolf WHM, Wouters, Emiel FM, Janssen, Daisy JA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182042/
https://www.ncbi.nlm.nih.gov/pubmed/28031706
http://dx.doi.org/10.2147/COPD.S119633
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author Cleutjens, Fiona AHM
Franssen, Frits ME
Spruit, Martijn A
Vanfleteren, Lowie EGW
Gijsen, Candy
Dijkstra, Jeanette B
Ponds, Rudolf WHM
Wouters, Emiel FM
Janssen, Daisy JA
author_facet Cleutjens, Fiona AHM
Franssen, Frits ME
Spruit, Martijn A
Vanfleteren, Lowie EGW
Gijsen, Candy
Dijkstra, Jeanette B
Ponds, Rudolf WHM
Wouters, Emiel FM
Janssen, Daisy JA
author_sort Cleutjens, Fiona AHM
collection PubMed
description Impaired cognitive function is increasingly recognized in COPD. Yet, the prevalence of cognitive impairment in specific cognitive domains in COPD has been poorly studied. The aim of this cross-sectional observational study was to compare the prevalence of domain-specific cognitive impairment between patients with COPD and non-COPD controls. A neuropsychological assessment was administered in 90 stable COPD patients and 90 non-COPD controls with comparable smoking status, age, and level of education. Six core tests from the Maastricht Aging Study were used to assess general cognitive impairment. By using Z-scores, compound scores were constructed for the following domains: psychomotor speed, planning, working memory, verbal memory, and cognitive flexibility. General cognitive impairment and domain-specific cognitive impairment were compared between COPD patients and controls after correction for comorbidities using multivariate linear and logistic regression models. General cognitive impairment was found in 56.7% of patients with COPD and in 13.3% of controls. Deficits in the following domains were more often present in patients with COPD after correction for comorbidities: psychomotor speed (17.8% vs 3.3%; P<0.001), planning (17.8% vs 1.1%; P<0.001), and cognitive flexibility (43.3% vs 12.2%; P<0.001). General cognitive impairment and impairments in the domains psychomotor speed, planning, and cognitive flexibility affect the COPD patients more than their matched controls.
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spelling pubmed-51820422016-12-28 Domain-specific cognitive impairment in patients with COPD and control subjects Cleutjens, Fiona AHM Franssen, Frits ME Spruit, Martijn A Vanfleteren, Lowie EGW Gijsen, Candy Dijkstra, Jeanette B Ponds, Rudolf WHM Wouters, Emiel FM Janssen, Daisy JA Int J Chron Obstruct Pulmon Dis Original Research Impaired cognitive function is increasingly recognized in COPD. Yet, the prevalence of cognitive impairment in specific cognitive domains in COPD has been poorly studied. The aim of this cross-sectional observational study was to compare the prevalence of domain-specific cognitive impairment between patients with COPD and non-COPD controls. A neuropsychological assessment was administered in 90 stable COPD patients and 90 non-COPD controls with comparable smoking status, age, and level of education. Six core tests from the Maastricht Aging Study were used to assess general cognitive impairment. By using Z-scores, compound scores were constructed for the following domains: psychomotor speed, planning, working memory, verbal memory, and cognitive flexibility. General cognitive impairment and domain-specific cognitive impairment were compared between COPD patients and controls after correction for comorbidities using multivariate linear and logistic regression models. General cognitive impairment was found in 56.7% of patients with COPD and in 13.3% of controls. Deficits in the following domains were more often present in patients with COPD after correction for comorbidities: psychomotor speed (17.8% vs 3.3%; P<0.001), planning (17.8% vs 1.1%; P<0.001), and cognitive flexibility (43.3% vs 12.2%; P<0.001). General cognitive impairment and impairments in the domains psychomotor speed, planning, and cognitive flexibility affect the COPD patients more than their matched controls. Dove Medical Press 2016-12-19 /pmc/articles/PMC5182042/ /pubmed/28031706 http://dx.doi.org/10.2147/COPD.S119633 Text en © 2017 Cleutjens et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Cleutjens, Fiona AHM
Franssen, Frits ME
Spruit, Martijn A
Vanfleteren, Lowie EGW
Gijsen, Candy
Dijkstra, Jeanette B
Ponds, Rudolf WHM
Wouters, Emiel FM
Janssen, Daisy JA
Domain-specific cognitive impairment in patients with COPD and control subjects
title Domain-specific cognitive impairment in patients with COPD and control subjects
title_full Domain-specific cognitive impairment in patients with COPD and control subjects
title_fullStr Domain-specific cognitive impairment in patients with COPD and control subjects
title_full_unstemmed Domain-specific cognitive impairment in patients with COPD and control subjects
title_short Domain-specific cognitive impairment in patients with COPD and control subjects
title_sort domain-specific cognitive impairment in patients with copd and control subjects
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182042/
https://www.ncbi.nlm.nih.gov/pubmed/28031706
http://dx.doi.org/10.2147/COPD.S119633
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