Cargando…

Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study

BACKGROUND: Despite available treatments, major depression is a highly heterogeneous disorder, which leads to problems in classification and treatment specificity. Previous studies have reported that personality traits predict and influence the course and treatment response of depression. The Temper...

Descripción completa

Detalles Bibliográficos
Autores principales: Kudo, Yuka, Nakagawa, Atsuo, Wake, Taisei, Ishikawa, Natsumi, Kurata, Chika, Nakahara, Mizuki, Nojima, Teruo, Mimura, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182045/
https://www.ncbi.nlm.nih.gov/pubmed/28031714
http://dx.doi.org/10.2147/NDT.S123788
_version_ 1782485817970655232
author Kudo, Yuka
Nakagawa, Atsuo
Wake, Taisei
Ishikawa, Natsumi
Kurata, Chika
Nakahara, Mizuki
Nojima, Teruo
Mimura, Masaru
author_facet Kudo, Yuka
Nakagawa, Atsuo
Wake, Taisei
Ishikawa, Natsumi
Kurata, Chika
Nakahara, Mizuki
Nojima, Teruo
Mimura, Masaru
author_sort Kudo, Yuka
collection PubMed
description BACKGROUND: Despite available treatments, major depression is a highly heterogeneous disorder, which leads to problems in classification and treatment specificity. Previous studies have reported that personality traits predict and influence the course and treatment response of depression. The Temperament and Personality Questionnaire (T&P) assesses eight major constructs of personality traits observed in those who develop depression. The aim of this study was to investigate the influence of T&P’s eight constructs on the treatment outcome of depressed patients. PATIENTS AND METHODS: A preliminary 6-month prospective study was conducted with a sample of 51 adult patients with a diagnosis of major depressive disorder (MDD) without remarkable psychomotor disturbance using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. All patients received comprehensive assessment including the T&P at baseline. We compared each T&P construct score between patients who achieved remission and those who did not achieve remission after 6 months of treatment for depression using both subjective and objective measures. All 51 (100%) patients received the 6-month follow-up assessment. RESULTS: This study demonstrated that higher scores on T&P personal reserve predicted poorer treatment outcome in patients with MDD. Higher levels of personal reserve, rejection sensitivity, and self-criticism correlated with higher levels of depression. Higher levels of rejection sensitivity and self-criticism were associated with non-remitters; however, when we controlled for baseline depression severity, this relationship did not show significance. CONCLUSION: Although the results are preliminary, this study suggests that high scores on T&P personal reserve predict poorer treatment outcome and T&P rejection sensitivity and self-criticism correlate with the severity of depression. Longer follow-up studies with large sample sizes are required to improve the understanding of these relationships.
format Online
Article
Text
id pubmed-5182045
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-51820452016-12-28 Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study Kudo, Yuka Nakagawa, Atsuo Wake, Taisei Ishikawa, Natsumi Kurata, Chika Nakahara, Mizuki Nojima, Teruo Mimura, Masaru Neuropsychiatr Dis Treat Original Research BACKGROUND: Despite available treatments, major depression is a highly heterogeneous disorder, which leads to problems in classification and treatment specificity. Previous studies have reported that personality traits predict and influence the course and treatment response of depression. The Temperament and Personality Questionnaire (T&P) assesses eight major constructs of personality traits observed in those who develop depression. The aim of this study was to investigate the influence of T&P’s eight constructs on the treatment outcome of depressed patients. PATIENTS AND METHODS: A preliminary 6-month prospective study was conducted with a sample of 51 adult patients with a diagnosis of major depressive disorder (MDD) without remarkable psychomotor disturbance using the Diagnostic and Statistical Manual of Mental Disorders, fourth edition. All patients received comprehensive assessment including the T&P at baseline. We compared each T&P construct score between patients who achieved remission and those who did not achieve remission after 6 months of treatment for depression using both subjective and objective measures. All 51 (100%) patients received the 6-month follow-up assessment. RESULTS: This study demonstrated that higher scores on T&P personal reserve predicted poorer treatment outcome in patients with MDD. Higher levels of personal reserve, rejection sensitivity, and self-criticism correlated with higher levels of depression. Higher levels of rejection sensitivity and self-criticism were associated with non-remitters; however, when we controlled for baseline depression severity, this relationship did not show significance. CONCLUSION: Although the results are preliminary, this study suggests that high scores on T&P personal reserve predict poorer treatment outcome and T&P rejection sensitivity and self-criticism correlate with the severity of depression. Longer follow-up studies with large sample sizes are required to improve the understanding of these relationships. Dove Medical Press 2016-12-19 /pmc/articles/PMC5182045/ /pubmed/28031714 http://dx.doi.org/10.2147/NDT.S123788 Text en © 2017 Kudo et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Kudo, Yuka
Nakagawa, Atsuo
Wake, Taisei
Ishikawa, Natsumi
Kurata, Chika
Nakahara, Mizuki
Nojima, Teruo
Mimura, Masaru
Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_full Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_fullStr Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_full_unstemmed Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_short Temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
title_sort temperament, personality, and treatment outcome in major depression: a 6-month preliminary prospective study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182045/
https://www.ncbi.nlm.nih.gov/pubmed/28031714
http://dx.doi.org/10.2147/NDT.S123788
work_keys_str_mv AT kudoyuka temperamentpersonalityandtreatmentoutcomeinmajordepressiona6monthpreliminaryprospectivestudy
AT nakagawaatsuo temperamentpersonalityandtreatmentoutcomeinmajordepressiona6monthpreliminaryprospectivestudy
AT waketaisei temperamentpersonalityandtreatmentoutcomeinmajordepressiona6monthpreliminaryprospectivestudy
AT ishikawanatsumi temperamentpersonalityandtreatmentoutcomeinmajordepressiona6monthpreliminaryprospectivestudy
AT kuratachika temperamentpersonalityandtreatmentoutcomeinmajordepressiona6monthpreliminaryprospectivestudy
AT nakaharamizuki temperamentpersonalityandtreatmentoutcomeinmajordepressiona6monthpreliminaryprospectivestudy
AT nojimateruo temperamentpersonalityandtreatmentoutcomeinmajordepressiona6monthpreliminaryprospectivestudy
AT mimuramasaru temperamentpersonalityandtreatmentoutcomeinmajordepressiona6monthpreliminaryprospectivestudy