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Ric-8A, a G protein chaperone with nucleotide exchange activity induces long-range secondary structure changes in Gα

Cytosolic Ric-8A has guanine nucleotide exchange factor (GEF) activity and is a chaperone for several classes of heterotrimeric G protein α subunits in vertebrates. Using Hydrogen-Deuterium Exchange-Mass Spectrometry (HDX-MS) we show that Ric-8A disrupts the secondary structure of the Gα Ras-like do...

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Detalles Bibliográficos
Autores principales:	Kant, Ravi, Zeng, Baisen, Thomas, Celestine J, Bothner, Brian, Sprang, Stephen R
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2016
Materias:	Biochemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182059/ https://www.ncbi.nlm.nih.gov/pubmed/28008853 http://dx.doi.org/10.7554/eLife.19238

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