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Mechanism of allosteric regulation of β(2)-adrenergic receptor by cholesterol

There is evidence that lipids can be allosteric regulators of membrane protein structure and activation. However, there are no data showing how exactly the regulation emerges from specific lipid-protein interactions. Here we show in atomistic detail how the human β(2)-adrenergic receptor (β(2)AR) –...

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Detalles Bibliográficos
Autores principales: Manna, Moutusi, Niemelä, Miia, Tynkkynen, Joona, Javanainen, Matti, Kulig, Waldemar, Müller, Daniel J, Rog, Tomasz, Vattulainen, Ilpo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5182060/
https://www.ncbi.nlm.nih.gov/pubmed/27897972
http://dx.doi.org/10.7554/eLife.18432

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