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Blockade of Serotonin 5-HT(2A) Receptors Suppresses Behavioral Sensitization and Naloxone-Precipitated Withdrawal Symptoms in Morphine-Treated Mice
The increasing prescription of opioids is fueling an epidemic of addiction and overdose deaths. Morphine is a highly addictive drug characterized by a high relapse rate – even after a long period of abstinence. Serotonin (5-HT) neurotransmission participates in the development of morphine dependence...
Autores principales: | Pang, Gang, Wu, Xian, Tao, Xinrong, Mao, Ruoying, Liu, Xueke, Zhang, Yong-Mei, Li, Guangwu, Stackman, Robert W., Dong, Liuyi, Zhang, Gongliang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183621/ https://www.ncbi.nlm.nih.gov/pubmed/28082900 http://dx.doi.org/10.3389/fphar.2016.00514 |
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