FUS Mislocalization and Vulnerability to DNA Damage in ALS Patients Derived hiPSCs and Aging Motoneurons

Mutations within the FUS gene (Fused in Sarcoma) are known to cause Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease affecting upper and lower motoneurons. The FUS gene codes for a multifunctional RNA/DNA-binding protein that is primarily localized in the nucleus and is involved in c...

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Detalles Bibliográficos
Autores principales: Higelin, Julia, Demestre, Maria, Putz, Stefan, Delling, Jan P., Jacob, Christian, Lutz, Anne-Kathrin, Bausinger, Julia, Huber, Anne-Kathrin, Klingenstein, Moritz, Barbi, Gotthold, Speit, Günter, Huebers, Annemarie, Weishaupt, Jochen H., Hermann, Andreas, Liebau, Stefan, Ludolph, Albert C., Boeckers, Tobias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183648/
https://www.ncbi.nlm.nih.gov/pubmed/28082870
http://dx.doi.org/10.3389/fncel.2016.00290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183648/
https://www.ncbi.nlm.nih.gov/pubmed/28082870
http://dx.doi.org/10.3389/fncel.2016.00290

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