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Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study

AIM: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. METHODS: We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped...

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Autores principales: Ajdacic-Gross, Vladeta, Aleksandrowicz, Aleksandra, Rodgers, Stephanie, Mutsch, Margot, Tesic, Anja, Müller, Mario, Kawohl, Wolfram, Rössler, Wulf, Seifritz, Erich, Castelao, Enrique, Strippoli, Marie-Pierre F, Vandeleur, Caroline, von Känel, Roland, Paolicelli, Rosa, Landolt, Markus A, Witthauer, Cornelia, Lieb, Roselind, Preisig, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183994/
https://www.ncbi.nlm.nih.gov/pubmed/28078206
http://dx.doi.org/10.5498/wjp.v6.i4.419
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author Ajdacic-Gross, Vladeta
Aleksandrowicz, Aleksandra
Rodgers, Stephanie
Mutsch, Margot
Tesic, Anja
Müller, Mario
Kawohl, Wolfram
Rössler, Wulf
Seifritz, Erich
Castelao, Enrique
Strippoli, Marie-Pierre F
Vandeleur, Caroline
von Känel, Roland
Paolicelli, Rosa
Landolt, Markus A
Witthauer, Cornelia
Lieb, Roselind
Preisig, Martin
author_facet Ajdacic-Gross, Vladeta
Aleksandrowicz, Aleksandra
Rodgers, Stephanie
Mutsch, Margot
Tesic, Anja
Müller, Mario
Kawohl, Wolfram
Rössler, Wulf
Seifritz, Erich
Castelao, Enrique
Strippoli, Marie-Pierre F
Vandeleur, Caroline
von Känel, Roland
Paolicelli, Rosa
Landolt, Markus A
Witthauer, Cornelia
Lieb, Roselind
Preisig, Martin
author_sort Ajdacic-Gross, Vladeta
collection PubMed
description AIM: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. METHODS: We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS: Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders (men), and measles/mumps/rubella-infections with early and late anxiety disorders (women). Gastric inflammatory diseases took effect in mood disorders (both sexes) and in early disorders (men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne (associations with mood disorders in men) and psoriasis (associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders (men), and neurodevelopmental and early anxiety disorders (women). CONCLUSION: Infectious, atopic and inflammatory diseases are important risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced.
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spelling pubmed-51839942017-01-11 Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study Ajdacic-Gross, Vladeta Aleksandrowicz, Aleksandra Rodgers, Stephanie Mutsch, Margot Tesic, Anja Müller, Mario Kawohl, Wolfram Rössler, Wulf Seifritz, Erich Castelao, Enrique Strippoli, Marie-Pierre F Vandeleur, Caroline von Känel, Roland Paolicelli, Rosa Landolt, Markus A Witthauer, Cornelia Lieb, Roselind Preisig, Martin World J Psychiatry Retrospective Study AIM: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. METHODS: We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS: Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders (men), and measles/mumps/rubella-infections with early and late anxiety disorders (women). Gastric inflammatory diseases took effect in mood disorders (both sexes) and in early disorders (men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne (associations with mood disorders in men) and psoriasis (associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders (men), and neurodevelopmental and early anxiety disorders (women). CONCLUSION: Infectious, atopic and inflammatory diseases are important risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. Baishideng Publishing Group Inc 2016-12-22 /pmc/articles/PMC5183994/ /pubmed/28078206 http://dx.doi.org/10.5498/wjp.v6.i4.419 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Retrospective Study
Ajdacic-Gross, Vladeta
Aleksandrowicz, Aleksandra
Rodgers, Stephanie
Mutsch, Margot
Tesic, Anja
Müller, Mario
Kawohl, Wolfram
Rössler, Wulf
Seifritz, Erich
Castelao, Enrique
Strippoli, Marie-Pierre F
Vandeleur, Caroline
von Känel, Roland
Paolicelli, Rosa
Landolt, Markus A
Witthauer, Cornelia
Lieb, Roselind
Preisig, Martin
Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study
title Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study
title_full Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study
title_fullStr Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study
title_full_unstemmed Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study
title_short Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study
title_sort infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: results from a large swiss epidemiological study
topic Retrospective Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183994/
https://www.ncbi.nlm.nih.gov/pubmed/28078206
http://dx.doi.org/10.5498/wjp.v6.i4.419
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