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Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study
AIM: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. METHODS: We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Baishideng Publishing Group Inc
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183994/ https://www.ncbi.nlm.nih.gov/pubmed/28078206 http://dx.doi.org/10.5498/wjp.v6.i4.419 |
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author | Ajdacic-Gross, Vladeta Aleksandrowicz, Aleksandra Rodgers, Stephanie Mutsch, Margot Tesic, Anja Müller, Mario Kawohl, Wolfram Rössler, Wulf Seifritz, Erich Castelao, Enrique Strippoli, Marie-Pierre F Vandeleur, Caroline von Känel, Roland Paolicelli, Rosa Landolt, Markus A Witthauer, Cornelia Lieb, Roselind Preisig, Martin |
author_facet | Ajdacic-Gross, Vladeta Aleksandrowicz, Aleksandra Rodgers, Stephanie Mutsch, Margot Tesic, Anja Müller, Mario Kawohl, Wolfram Rössler, Wulf Seifritz, Erich Castelao, Enrique Strippoli, Marie-Pierre F Vandeleur, Caroline von Känel, Roland Paolicelli, Rosa Landolt, Markus A Witthauer, Cornelia Lieb, Roselind Preisig, Martin |
author_sort | Ajdacic-Gross, Vladeta |
collection | PubMed |
description | AIM: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. METHODS: We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS: Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders (men), and measles/mumps/rubella-infections with early and late anxiety disorders (women). Gastric inflammatory diseases took effect in mood disorders (both sexes) and in early disorders (men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne (associations with mood disorders in men) and psoriasis (associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders (men), and neurodevelopmental and early anxiety disorders (women). CONCLUSION: Infectious, atopic and inflammatory diseases are important risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. |
format | Online Article Text |
id | pubmed-5183994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-51839942017-01-11 Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study Ajdacic-Gross, Vladeta Aleksandrowicz, Aleksandra Rodgers, Stephanie Mutsch, Margot Tesic, Anja Müller, Mario Kawohl, Wolfram Rössler, Wulf Seifritz, Erich Castelao, Enrique Strippoli, Marie-Pierre F Vandeleur, Caroline von Känel, Roland Paolicelli, Rosa Landolt, Markus A Witthauer, Cornelia Lieb, Roselind Preisig, Martin World J Psychiatry Retrospective Study AIM: To examine the associations between mental disorders and infectious, atopic, inflammatory diseases while adjusting for other risk factors. METHODS: We used data from PsyCoLaus, a large Swiss Population Cohort Study (n = 3720; age range 35-66). Lifetime diagnoses of mental disorders were grouped into the following categories: Neurodevelopmental, anxiety (early and late onset), mood and substance disorders. They were regressed on infectious, atopic and other inflammatory diseases adjusting for sex, educational level, familial aggregation, childhood adversities and traumatic experiences in childhood. A multivariate logistic regression was applied to each group of disorders. In a complementary analysis interactions with sex were introduced via nested effects. RESULTS: Associations with infectious, atopic and other chronic inflammatory diseases were observable together with consistent effects of childhood adversities and familial aggregation, and less consistent effects of trauma in each group of mental disorders. Streptococcal infections were associated with neurodevelopmental disorders (men), and measles/mumps/rubella-infections with early and late anxiety disorders (women). Gastric inflammatory diseases took effect in mood disorders (both sexes) and in early disorders (men). Similarly, irritable bowel syndrome was prominent in a sex-specific way in mood disorders in women, and, moreover, was associated with early and late anxiety disorders. Atopic diseases were associated with late anxiety disorders. Acne (associations with mood disorders in men) and psoriasis (associations with early anxiety disorders in men and mood disorders in women) contributed sex-specific results. Urinary tract infections were associated with mood disorders and, in addition, in a sex-specific way with late anxiety disorders (men), and neurodevelopmental and early anxiety disorders (women). CONCLUSION: Infectious, atopic and inflammatory diseases are important risk factors for all groups of mental disorders. The sexual dimorphism of the associations is pronounced. Baishideng Publishing Group Inc 2016-12-22 /pmc/articles/PMC5183994/ /pubmed/28078206 http://dx.doi.org/10.5498/wjp.v6.i4.419 Text en ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Retrospective Study Ajdacic-Gross, Vladeta Aleksandrowicz, Aleksandra Rodgers, Stephanie Mutsch, Margot Tesic, Anja Müller, Mario Kawohl, Wolfram Rössler, Wulf Seifritz, Erich Castelao, Enrique Strippoli, Marie-Pierre F Vandeleur, Caroline von Känel, Roland Paolicelli, Rosa Landolt, Markus A Witthauer, Cornelia Lieb, Roselind Preisig, Martin Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study |
title | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study |
title_full | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study |
title_fullStr | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study |
title_full_unstemmed | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study |
title_short | Infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: Results from a large Swiss epidemiological study |
title_sort | infectious, atopic and inflammatory diseases, childhood adversities and familial aggregation are independently associated with the risk for mental disorders: results from a large swiss epidemiological study |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183994/ https://www.ncbi.nlm.nih.gov/pubmed/28078206 http://dx.doi.org/10.5498/wjp.v6.i4.419 |
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