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Simple Strategy for Taming Membrane-Disrupting Antibiotics
[Image: see text] A strategy has been devised for increasing the cellular selectivity of membrane-disrupting antibiotics based on the attachment of a facially amphiphilic sterol. Using Amphotericin B (AmB) as a prototype, covalent attachment of cholic acid bound to a series of α,ω-diamines has led t...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184371/ https://www.ncbi.nlm.nih.gov/pubmed/27801580 http://dx.doi.org/10.1021/acs.bioconjchem.6b00629 |