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11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet

The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) interconverts active glucocorticoids and their intrinsically inert 11-keto forms. The type 1 isozyme, 11β-HSD1, predominantly reactivates glucocorticoids in vivo and can also metabolise bile acids. 11β-HSD1-deficient mice show altered inflammator...

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Detalles Bibliográficos
Autores principales:	Johnson, Jethro S, Opiyo, Monica N, Thomson, Marian, Gharbi, Karim, Seckl, Jonathan R, Heger, Andreas, Chapman, Karen E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184774/ https://www.ncbi.nlm.nih.gov/pubmed/27885053 http://dx.doi.org/10.1530/JOE-16-0578

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