Cargando…

11β-hydroxysteroid dehydrogenase-1 deficiency alters the gut microbiome response to Western diet

The enzyme 11β-hydroxysteroid dehydrogenase (11β-HSD) interconverts active glucocorticoids and their intrinsically inert 11-keto forms. The type 1 isozyme, 11β-HSD1, predominantly reactivates glucocorticoids in vivo and can also metabolise bile acids. 11β-HSD1-deficient mice show altered inflammator...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnson, Jethro S, Opiyo, Monica N, Thomson, Marian, Gharbi, Karim, Seckl, Jonathan R, Heger, Andreas, Chapman, Karen E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184774/ https://www.ncbi.nlm.nih.gov/pubmed/27885053 http://dx.doi.org/10.1530/JOE-16-0578

Ejemplares similares

Modulation of 11β-Hydroxysteroid Dehydrogenase as a Strategy to Reduce Vascular Inflammation
por: Hadoke, Patrick W. F., et al.
Publicado: (2013)

11β-hydroxysteroid dehydrogenase-1 deficiency alters brain energy metabolism in acute systemic inflammation
por: Verma, Manu, et al.
Publicado: (2018)

Changing glucocorticoid action: 11β-Hydroxysteroid dehydrogenase type 1 in acute and chronic inflammation
por: Chapman, Karen E., et al.
Publicado: (2013)

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice
por: Coutinho, Agnes E., et al.
Publicado: (2012)

11β-Hydroxysteroid dehydrogenases and the brain: From zero to hero, a decade of progress
por: Wyrwoll, Caitlin S., et al.
Publicado: (2011)

11β-hydroxysteroid dehydrogenase type 1 deficiency in bone marrow-derived cells reduces atherosclerosis
por: Kipari, Tiina, et al.
Publicado: (2013)

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
por: Kosicka, Katarzyna, et al.
Publicado: (2016)

Mast Cells Express 11β-hydroxysteroid Dehydrogenase Type 1: A Role in Restraining Mast Cell Degranulation
por: Coutinho, Agnes E., et al.
Publicado: (2013)

11β-Hydroxysteroid Dehydrogenase Type 1 Is Expressed in Neutrophils and Restrains an Inflammatory Response in Male Mice
por: Coutinho, Agnes E., et al.
Publicado: (2016)

Novel Fat Depot–Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11β-Hydroxysteroid Dehydrogenase Type 1–Deficient Mice
por: Wamil, Malgorzata, et al.
Publicado: (2011)

11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome
por: Bailey, Matthew A.
Publicado: (2017)

The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity
por: Nakata, Takaya, et al.
Publicado: (2016)

11Beta‐hydroxysteroid dehydrogenase‐1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis
por: Zou, Xiantong, et al.
Publicado: (2018)

Idiopathic intracranial hypertension, hormones, and 11β-hydroxysteroid dehydrogenases
por: Markey, Keira A, et al.
Publicado: (2016)

Cortisol, Hypertension and Obesity: The Role of 11β-Hydroxysteroid Dehydrogenase
por: Stewart, Paul M
Publicado: (1998)

Regulation of Adipocyte 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) by CCAAT/Enhancer-Binding Protein (C/EBP) β Isoforms, LIP and LAP
por: Esteves, Cristina L., et al.
Publicado: (2012)

Increased Angiogenesis Protects against Adipose Hypoxia and Fibrosis in Metabolic Disease-resistant 11β-Hydroxysteroid Dehydrogenase Type 1 (HSD1)-deficient Mice
por: Michailidou, Zoi, et al.
Publicado: (2012)

Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure
por: Turban, Sophie, et al.
Publicado: (2012)

Effect of Luteolin on 11Beta-Hydroxysteroid Dehydrogenase in Rat Liver and Kidney
por: Tang, Lei, et al.
Publicado: (2015)

Diethylstilbestrol inhibits human and rat 11β-hydroxysteroid dehydrogenase 2
por: Wang, Yiyan, et al.
Publicado: (2019)

Pro-Inflammatory Cytokine Induction of 11β-hydroxysteroid Dehydrogenase Type 1 in A549 Cells Requires Phosphorylation of C/EBPβ at Thr235
por: Esteves, Cristina L., et al.
Publicado: (2013)

A Calcium-Deficient Diet in Rat Dams during Gestation and Nursing Affects Hepatic 11β-hydroxysteroid dehydrogenase-1 Expression in the Offspring
por: Takaya, Junji, et al.
Publicado: (2014)

Prenatal Programming of Metabolic Syndrome in the Common Marmoset Is Associated With Increased Expression of 11β-Hydroxysteroid Dehydrogenase Type 1
por: Nyirenda, Moffat J., et al.
Publicado: (2009)

Cardiomyocyte and Vascular Smooth Muscle-Independent 11β-Hydroxysteroid Dehydrogenase 1 Amplifies Infarct Expansion, Hypertrophy, and the Development of Heart Failure After Myocardial Infarction in Male Mice
por: White, Christopher I., et al.
Publicado: (2016)

Effect of Eclipta prostrata on 11Beta-Hydroxysteroid Dehydrogenase in Rat Liver and Kidney
por: Xu, Chenshu, et al.
Publicado: (2014)

Zearalenone Inhibits Rat and Human 11β-Hydroxysteroid Dehydrogenase Type 2
por: Li, Linxi, et al.
Publicado: (2015)

Changes in 11β-Hydroxysteroid Dehydrogenase and Glucocorticoid Receptor Expression in Kawasaki Disease
por: Wang, Juanli, et al.
Publicado: (2017)

Role of 11β-hydroxysteroid dehydrogenase type 1 in the development of atopic dermatitis
por: Lee, Noo Ri, et al.
Publicado: (2020)

Clinical and molecular characterization of patients with classic 3β-hydroxysteroid dehydrogenase deficiency
por: Wiromrat, Pattara, et al.
Publicado: (2015)

Genotype, Mortality, Morbidity, and Outcomes of 3β-Hydroxysteroid Dehydrogenase Deficiency in Algeria
por: Ladjouze, Asmahane, et al.
Publicado: (2022)

Approach of Heterogeneous Spectrum Involving 3beta-Hydroxysteroid Dehydrogenase 2 Deficiency
por: Nicola, Andreea Gabriela, et al.
Publicado: (2022)

Selection and early clinical evaluation of the brain‐penetrant 11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) inhibitor UE2343 (Xanamem™)
por: Webster, Scott P, et al.
Publicado: (2017)

Response to Comment on: Turban et al. Optimal Elevation of β-Cell 11β-Hydroxysteroid Dehydrogenase Type 1 Is a Compensatory Mechanism That Prevents High-Fat Diet–Induced β-Cell Failure. Diabetes 2012;61:642–652
por: Turban, Sophie, et al.
Publicado: (2012)

Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease
por: Sooy, Karen, et al.
Publicado: (2015)

Posaconazole-Induced Hypertension Due to Inhibition of 11β-Hydroxylase and 11β-Hydroxysteroid Dehydrogenase 2
por: Thompson, George R, et al.
Publicado: (2019)

Patterning in Placental 11-B Hydroxysteroid Dehydrogenase Methylation According to Prenatal Socioeconomic Adversity
por: Appleton, Allison A., et al.
Publicado: (2013)

The expression of 11β-hydroxysteroid dehydrogenase type 1 is increased in experimental periodontitis in rats
por: Nakata, Takaya, et al.
Publicado: (2016)

Application of ELISA Technique and Human Microsomes in the Search for 11β-Hydroxysteroid Dehydrogenase Inhibitors
por: Kupczyk, Daria, et al.
Publicado: (2019)

Influence of labor on direct and indirect determinants of placental 11beta-hydroxysteroid dehydrogenase activity
por: Huebner, Hanna, et al.
Publicado: (2020)

Selective Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Attenuates High-Fat Diet-Induced Hepatic Steatosis in Mice
por: Li, Huashan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6m9hgk6gpdnsvfcv7okfi328q5