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Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center
The effectiveness of medications for PTSD in general has been well studied, but the effectiveness of medicatio.ns prescribed specifically for post-traumatic stress disorder (PTSD) nightmares is less well known. This retrospective chart review examined the efficacy of various medications used in actu...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184790/ https://www.ncbi.nlm.nih.gov/pubmed/27999253 http://dx.doi.org/10.3390/jcm5120117 |
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author | Detweiler, Mark B. Pagadala, Bhuvaneshwar Candelario, Joseph Boyle, Jennifer S. Detweiler, Jonna G. Lutgens, Brian W. |
author_facet | Detweiler, Mark B. Pagadala, Bhuvaneshwar Candelario, Joseph Boyle, Jennifer S. Detweiler, Jonna G. Lutgens, Brian W. |
author_sort | Detweiler, Mark B. |
collection | PubMed |
description | The effectiveness of medications for PTSD in general has been well studied, but the effectiveness of medicatio.ns prescribed specifically for post-traumatic stress disorder (PTSD) nightmares is less well known. This retrospective chart review examined the efficacy of various medications used in actual treatment of PTSD nightmares at one Veteran Affairs Hospital. Records at the Salem, VA Veterans Affairs Medical Center (VAMC) were examined from 2009 to 2013 to check for the efficacy of actual treatments used in comparis.on with treatments suggested in three main review articles. The final sample consisted of 327 patients and 478 separate medication trials involving 21 individual medications plus 13 different medication combinations. The three most frequently utilized medications were prazosin (107 trials), risperidone (81 trials), and quetiapine (72 trials). Five medications had 20 or more trials with successful results (partial to full nightmare cessation) in >50% of trials: risperidone (77%, 1.0–6.0 mg), clonidine (63%, 0.1–2.0 mg), quetiapine (50%, 12.5–800.0 mg), mirtazapine (50%; 7.5–30.0 mg), and terazosin (64%, 50.0–300.0 mg). Notably, olanzapine (2.5–10.0) was successful (full remission) in all five prescription trials in five separate patients. Based on the clinical results, the use of risperidone, clonidine, terazosin, and olanzapine warrants additional investigation in clinically controlled trials as medications prescribed specifically for PTSD nightmares. |
format | Online Article Text |
id | pubmed-5184790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51847902016-12-30 Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center Detweiler, Mark B. Pagadala, Bhuvaneshwar Candelario, Joseph Boyle, Jennifer S. Detweiler, Jonna G. Lutgens, Brian W. J Clin Med Article The effectiveness of medications for PTSD in general has been well studied, but the effectiveness of medicatio.ns prescribed specifically for post-traumatic stress disorder (PTSD) nightmares is less well known. This retrospective chart review examined the efficacy of various medications used in actual treatment of PTSD nightmares at one Veteran Affairs Hospital. Records at the Salem, VA Veterans Affairs Medical Center (VAMC) were examined from 2009 to 2013 to check for the efficacy of actual treatments used in comparis.on with treatments suggested in three main review articles. The final sample consisted of 327 patients and 478 separate medication trials involving 21 individual medications plus 13 different medication combinations. The three most frequently utilized medications were prazosin (107 trials), risperidone (81 trials), and quetiapine (72 trials). Five medications had 20 or more trials with successful results (partial to full nightmare cessation) in >50% of trials: risperidone (77%, 1.0–6.0 mg), clonidine (63%, 0.1–2.0 mg), quetiapine (50%, 12.5–800.0 mg), mirtazapine (50%; 7.5–30.0 mg), and terazosin (64%, 50.0–300.0 mg). Notably, olanzapine (2.5–10.0) was successful (full remission) in all five prescription trials in five separate patients. Based on the clinical results, the use of risperidone, clonidine, terazosin, and olanzapine warrants additional investigation in clinically controlled trials as medications prescribed specifically for PTSD nightmares. MDPI 2016-12-16 /pmc/articles/PMC5184790/ /pubmed/27999253 http://dx.doi.org/10.3390/jcm5120117 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Detweiler, Mark B. Pagadala, Bhuvaneshwar Candelario, Joseph Boyle, Jennifer S. Detweiler, Jonna G. Lutgens, Brian W. Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center |
title | Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center |
title_full | Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center |
title_fullStr | Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center |
title_full_unstemmed | Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center |
title_short | Treatment of Post-Traumatic Stress Disorder Nightmares at a Veterans Affairs Medical Center |
title_sort | treatment of post-traumatic stress disorder nightmares at a veterans affairs medical center |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184790/ https://www.ncbi.nlm.nih.gov/pubmed/27999253 http://dx.doi.org/10.3390/jcm5120117 |
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