Inactivation of Sonic Hedgehog Signaling and Polydactyly in Limbs of Hereditary Multiple Malformation, a Novel Type of Talpid Mutant

Hereditary Multiple Malformation (HMM) is a naturally occurring, autosomal recessive, homozygous lethal mutation found in Japanese quail. Homozygote embryos (hmm(−/−)) show polydactyly similar to talpid(2) and talpid(3) mutants. Here we characterize the molecular profile of the hmm(−/−) limb bud and...

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Detalles Bibliográficos
Autores principales: Matsubara, Yoshiyuki, Nakano, Mikiharu, Kawamura, Kazuki, Tsudzuki, Masaoki, Funahashi, Jun-Ichi, Agata, Kiyokazu, Matsuda, Yoichi, Kuroiwa, Atsushi, Suzuki, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Cell and Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187386/
https://www.ncbi.nlm.nih.gov/pubmed/28083533
http://dx.doi.org/10.3389/fcell.2016.00149

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