Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway

The mTOR complex I (mTORC1) signaling pathway controls many metabolic processes and is regulated by amino acid signals, especially arginine. CASTOR1 has been identified as the cytosolic arginine sensor for the mTORC1 pathway, but the molecular mechanism of how it senses arginine is elusive. Here, by...

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Detalles Bibliográficos
Autores principales: Gai, Zhongchao, Wang, Qian, Yang, Can, Wang, Lei, Deng, Wei, Wu, Geng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187391/
https://www.ncbi.nlm.nih.gov/pubmed/28066558
http://dx.doi.org/10.1038/celldisc.2016.51

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