A bromodomain–DNA interaction facilitates acetylation-dependent bivalent nucleosome recognition by the BET protein BRDT

Bromodomains are critical components of many chromatin modifying/remodelling proteins and are emerging therapeutic targets, yet how they interact with nucleosomes, rather than acetylated peptides, remains unclear. Using BRDT as a model, we characterized how the BET family of bromodomains interacts w...

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Detalles Bibliográficos
Autores principales: Miller, Thomas C. R., Simon, Bernd, Rybin, Vladimir, Grötsch, Helga, Curtet, Sandrine, Khochbin, Saadi, Carlomagno, Teresa, Müller, Christoph W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187433/
https://www.ncbi.nlm.nih.gov/pubmed/27991587
http://dx.doi.org/10.1038/ncomms13855

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