Reversible Vitamin B12 Deficiency Presenting with Acute Dementia, Paraparesis, and Normal Hemoglobin

Vitamin B12 is essential for neurological function and its deficiency is associated with many neuropsychiatric disorders. We report the case of a previously healthy 53-year-old male patient presenting with delirium and multiple neurological findings. Complete blood analysis indicated megaloblastic a...

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Autores principales: Almoallim, Hani, Mehdawi, Fahtima S., Cheikh, Mohammed M., Al-dhaheri, Fahmi, Aqeel, Abdullah Mahir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187480/
https://www.ncbi.nlm.nih.gov/pubmed/28070432
http://dx.doi.org/10.1155/2016/4301769
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author Almoallim, Hani
Mehdawi, Fahtima S.
Cheikh, Mohammed M.
Al-dhaheri, Fahmi
Aqeel, Abdullah Mahir
author_facet Almoallim, Hani
Mehdawi, Fahtima S.
Cheikh, Mohammed M.
Al-dhaheri, Fahmi
Aqeel, Abdullah Mahir
author_sort Almoallim, Hani
collection PubMed
description Vitamin B12 is essential for neurological function and its deficiency is associated with many neuropsychiatric disorders. We report the case of a previously healthy 53-year-old male patient presenting with delirium and multiple neurological findings. Complete blood analysis indicated megaloblastic anemia. All infectious causes were excluded owing to negative cultures (blood and urine). Tests for human immunodeficiency virus, syphilis, and toxoplasma were also negative. Metabolic workup showed severe vitamin B12 deficiency, decreased reticulocyte count, and increased direct bilirubin and lactate dehydrogenase. Intramuscular injection of cobalamin was started, and the patient showed significant improvement.
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spelling pubmed-51874802017-01-09 Reversible Vitamin B12 Deficiency Presenting with Acute Dementia, Paraparesis, and Normal Hemoglobin Almoallim, Hani Mehdawi, Fahtima S. Cheikh, Mohammed M. Al-dhaheri, Fahmi Aqeel, Abdullah Mahir Case Rep Neurol Med Case Report Vitamin B12 is essential for neurological function and its deficiency is associated with many neuropsychiatric disorders. We report the case of a previously healthy 53-year-old male patient presenting with delirium and multiple neurological findings. Complete blood analysis indicated megaloblastic anemia. All infectious causes were excluded owing to negative cultures (blood and urine). Tests for human immunodeficiency virus, syphilis, and toxoplasma were also negative. Metabolic workup showed severe vitamin B12 deficiency, decreased reticulocyte count, and increased direct bilirubin and lactate dehydrogenase. Intramuscular injection of cobalamin was started, and the patient showed significant improvement. Hindawi Publishing Corporation 2016 2016-12-13 /pmc/articles/PMC5187480/ /pubmed/28070432 http://dx.doi.org/10.1155/2016/4301769 Text en Copyright © 2016 Hani Almoallim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Almoallim, Hani
Mehdawi, Fahtima S.
Cheikh, Mohammed M.
Al-dhaheri, Fahmi
Aqeel, Abdullah Mahir
Reversible Vitamin B12 Deficiency Presenting with Acute Dementia, Paraparesis, and Normal Hemoglobin
title Reversible Vitamin B12 Deficiency Presenting with Acute Dementia, Paraparesis, and Normal Hemoglobin
title_full Reversible Vitamin B12 Deficiency Presenting with Acute Dementia, Paraparesis, and Normal Hemoglobin
title_fullStr Reversible Vitamin B12 Deficiency Presenting with Acute Dementia, Paraparesis, and Normal Hemoglobin
title_full_unstemmed Reversible Vitamin B12 Deficiency Presenting with Acute Dementia, Paraparesis, and Normal Hemoglobin
title_short Reversible Vitamin B12 Deficiency Presenting with Acute Dementia, Paraparesis, and Normal Hemoglobin
title_sort reversible vitamin b12 deficiency presenting with acute dementia, paraparesis, and normal hemoglobin
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187480/
https://www.ncbi.nlm.nih.gov/pubmed/28070432
http://dx.doi.org/10.1155/2016/4301769
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