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Androgen Receptor: A Complex Therapeutic Target for Breast Cancer

Molecular and histopathological profiling have classified breast cancer into multiple sub-types empowering precision treatment. Although estrogen receptor (ER) and human epidermal growth factor receptor (HER2) are the mainstay therapeutic targets in breast cancer, the androgen receptor (AR) is evolv...

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Detalles Bibliográficos
Autores principales: Narayanan, Ramesh, Dalton, James T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187506/
https://www.ncbi.nlm.nih.gov/pubmed/27918430
http://dx.doi.org/10.3390/cancers8120108
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author Narayanan, Ramesh
Dalton, James T.
author_facet Narayanan, Ramesh
Dalton, James T.
author_sort Narayanan, Ramesh
collection PubMed
description Molecular and histopathological profiling have classified breast cancer into multiple sub-types empowering precision treatment. Although estrogen receptor (ER) and human epidermal growth factor receptor (HER2) are the mainstay therapeutic targets in breast cancer, the androgen receptor (AR) is evolving as a molecular target for cancers that have developed resistance to conventional treatments. The high expression of AR in breast cancer and recent discovery and development of new nonsteroidal drugs targeting the AR provide a strong rationale for exploring it again as a therapeutic target in this disease. Ironically, both nonsteroidal agonists and antagonists for the AR are undergoing clinical trials, making AR a complicated target to understand in breast cancer. This review provides a detailed account of AR’s therapeutic role in breast cancer.
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spelling pubmed-51875062016-12-30 Androgen Receptor: A Complex Therapeutic Target for Breast Cancer Narayanan, Ramesh Dalton, James T. Cancers (Basel) Review Molecular and histopathological profiling have classified breast cancer into multiple sub-types empowering precision treatment. Although estrogen receptor (ER) and human epidermal growth factor receptor (HER2) are the mainstay therapeutic targets in breast cancer, the androgen receptor (AR) is evolving as a molecular target for cancers that have developed resistance to conventional treatments. The high expression of AR in breast cancer and recent discovery and development of new nonsteroidal drugs targeting the AR provide a strong rationale for exploring it again as a therapeutic target in this disease. Ironically, both nonsteroidal agonists and antagonists for the AR are undergoing clinical trials, making AR a complicated target to understand in breast cancer. This review provides a detailed account of AR’s therapeutic role in breast cancer. MDPI 2016-12-02 /pmc/articles/PMC5187506/ /pubmed/27918430 http://dx.doi.org/10.3390/cancers8120108 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Narayanan, Ramesh
Dalton, James T.
Androgen Receptor: A Complex Therapeutic Target for Breast Cancer
title Androgen Receptor: A Complex Therapeutic Target for Breast Cancer
title_full Androgen Receptor: A Complex Therapeutic Target for Breast Cancer
title_fullStr Androgen Receptor: A Complex Therapeutic Target for Breast Cancer
title_full_unstemmed Androgen Receptor: A Complex Therapeutic Target for Breast Cancer
title_short Androgen Receptor: A Complex Therapeutic Target for Breast Cancer
title_sort androgen receptor: a complex therapeutic target for breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187506/
https://www.ncbi.nlm.nih.gov/pubmed/27918430
http://dx.doi.org/10.3390/cancers8120108
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