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Protective Role of Dietary Berries in Cancer
Dietary patterns, including regular consumption of particular foods such as berries as well as bioactive compounds, may confer specific molecular and cellular protection in addition to the overall epidemiologically observed benefits of plant food consumption (lower rates of obesity and chronic disea...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187535/ https://www.ncbi.nlm.nih.gov/pubmed/27775562 http://dx.doi.org/10.3390/antiox5040037 |
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author | Kristo, Aleksandra S. Klimis-Zacas, Dorothy Sikalidis, Angelos K. |
author_facet | Kristo, Aleksandra S. Klimis-Zacas, Dorothy Sikalidis, Angelos K. |
author_sort | Kristo, Aleksandra S. |
collection | PubMed |
description | Dietary patterns, including regular consumption of particular foods such as berries as well as bioactive compounds, may confer specific molecular and cellular protection in addition to the overall epidemiologically observed benefits of plant food consumption (lower rates of obesity and chronic disease risk), further enhancing health. Mounting evidence reports a variety of health benefits of berry fruits that are usually attributed to their non-nutritive bioactive compounds, mainly phenolic substances such as flavonoids or anthocyanins. Although it is still unclear which particular constituents are responsible for the extended health benefits, it appears that whole berry consumption generally confers some anti-oxidant and anti-inflammatory protection to humans and animals. With regards to cancer, studies have reported beneficial effects of berries or their constituents including attenuation of inflammation, inhibition of angiogenesis, protection from DNA damage, as well as effects on apoptosis or proliferation rates of malignant cells. Berries extend effects on the proliferation rates of both premalignant and malignant cells. Their effect on premalignant cells is important for their ability to cause premalignant lesions to regress both in animals and in humans. The present review focuses primarily on in vivo and human dietary studies of various berry fruits and discusses whether regular dietary intake of berries can prevent cancer initiation and delay progression in humans or ameliorate patients’ cancer status. |
format | Online Article Text |
id | pubmed-5187535 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51875352016-12-30 Protective Role of Dietary Berries in Cancer Kristo, Aleksandra S. Klimis-Zacas, Dorothy Sikalidis, Angelos K. Antioxidants (Basel) Review Dietary patterns, including regular consumption of particular foods such as berries as well as bioactive compounds, may confer specific molecular and cellular protection in addition to the overall epidemiologically observed benefits of plant food consumption (lower rates of obesity and chronic disease risk), further enhancing health. Mounting evidence reports a variety of health benefits of berry fruits that are usually attributed to their non-nutritive bioactive compounds, mainly phenolic substances such as flavonoids or anthocyanins. Although it is still unclear which particular constituents are responsible for the extended health benefits, it appears that whole berry consumption generally confers some anti-oxidant and anti-inflammatory protection to humans and animals. With regards to cancer, studies have reported beneficial effects of berries or their constituents including attenuation of inflammation, inhibition of angiogenesis, protection from DNA damage, as well as effects on apoptosis or proliferation rates of malignant cells. Berries extend effects on the proliferation rates of both premalignant and malignant cells. Their effect on premalignant cells is important for their ability to cause premalignant lesions to regress both in animals and in humans. The present review focuses primarily on in vivo and human dietary studies of various berry fruits and discusses whether regular dietary intake of berries can prevent cancer initiation and delay progression in humans or ameliorate patients’ cancer status. MDPI 2016-10-19 /pmc/articles/PMC5187535/ /pubmed/27775562 http://dx.doi.org/10.3390/antiox5040037 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kristo, Aleksandra S. Klimis-Zacas, Dorothy Sikalidis, Angelos K. Protective Role of Dietary Berries in Cancer |
title | Protective Role of Dietary Berries in Cancer |
title_full | Protective Role of Dietary Berries in Cancer |
title_fullStr | Protective Role of Dietary Berries in Cancer |
title_full_unstemmed | Protective Role of Dietary Berries in Cancer |
title_short | Protective Role of Dietary Berries in Cancer |
title_sort | protective role of dietary berries in cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187535/ https://www.ncbi.nlm.nih.gov/pubmed/27775562 http://dx.doi.org/10.3390/antiox5040037 |
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