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Role of edaravone in managemant of septic peritonitis
BACKGROUND AND AIMS: Sepsis is a complex rapidly progressive infectious disease that remain a major cause of morbidity and mortality in surgical patients and trauma victims. Edaravone a novel free radical scavenger was approved in 2001 in Japan for treatment of acute cerebral and myocardial infarcti...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187610/ https://www.ncbi.nlm.nih.gov/pubmed/28096576 http://dx.doi.org/10.4103/0970-9185.194770 |
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author | Elbaradey, Ghada Fouad Elshmaa, Nagat Sayed Hodeib, Hossam |
author_facet | Elbaradey, Ghada Fouad Elshmaa, Nagat Sayed Hodeib, Hossam |
author_sort | Elbaradey, Ghada Fouad |
collection | PubMed |
description | BACKGROUND AND AIMS: Sepsis is a complex rapidly progressive infectious disease that remain a major cause of morbidity and mortality in surgical patients and trauma victims. Edaravone a novel free radical scavenger was approved in 2001 in Japan for treatment of acute cerebral and myocardial infarction. Hence, in this work we attempt to evaluate its role in cases of septic peritonitis (SP). MATERIAL AND METHODS: This is a prospective randomized observer-blinded study carried out in surgical Intensive Care Unit (ICU) after approval by Hospital Ethical Committee. After admission to ICU patients were randomly divided into two groups of thirty patients each-Group (C): Control group managed according to the routine protocol of sepsis and Group (E): Edaravone treated SP managed according to the routine protocol of sepsis + edaravone at dose of 30 mg/12 h intravenous infusion for 2 weeks. All patients were monitored for invasive blood pressure, central venous pressure, heart rate, temperature, urine output, total fluid balance, and routine investigation. Blood sample was taken weekly for 2 weeks to measure the following parameters: Nuclear transcription factor kappa B activity (NFKB), mitogen-activated protein kinase (MAPK), heat shock protein 72 (HSP 72) and total antioxidant capacity (TAC). RESULTS: There was significant decrease (P < 0.05) in serum level of NFKB, MAPK in Group E in comparison with Group C. While serum level of HSP 72 and TAC showed significant increase (P < 0.05) in Group E compared with Group C with better outcome. CONCLUSION: SP treatment with edaravone could significantly improve the inflammatory and oxidative states with better patient outcomes. |
format | Online Article Text |
id | pubmed-5187610 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51876102017-01-17 Role of edaravone in managemant of septic peritonitis Elbaradey, Ghada Fouad Elshmaa, Nagat Sayed Hodeib, Hossam J Anaesthesiol Clin Pharmacol Original Article BACKGROUND AND AIMS: Sepsis is a complex rapidly progressive infectious disease that remain a major cause of morbidity and mortality in surgical patients and trauma victims. Edaravone a novel free radical scavenger was approved in 2001 in Japan for treatment of acute cerebral and myocardial infarction. Hence, in this work we attempt to evaluate its role in cases of septic peritonitis (SP). MATERIAL AND METHODS: This is a prospective randomized observer-blinded study carried out in surgical Intensive Care Unit (ICU) after approval by Hospital Ethical Committee. After admission to ICU patients were randomly divided into two groups of thirty patients each-Group (C): Control group managed according to the routine protocol of sepsis and Group (E): Edaravone treated SP managed according to the routine protocol of sepsis + edaravone at dose of 30 mg/12 h intravenous infusion for 2 weeks. All patients were monitored for invasive blood pressure, central venous pressure, heart rate, temperature, urine output, total fluid balance, and routine investigation. Blood sample was taken weekly for 2 weeks to measure the following parameters: Nuclear transcription factor kappa B activity (NFKB), mitogen-activated protein kinase (MAPK), heat shock protein 72 (HSP 72) and total antioxidant capacity (TAC). RESULTS: There was significant decrease (P < 0.05) in serum level of NFKB, MAPK in Group E in comparison with Group C. While serum level of HSP 72 and TAC showed significant increase (P < 0.05) in Group E compared with Group C with better outcome. CONCLUSION: SP treatment with edaravone could significantly improve the inflammatory and oxidative states with better patient outcomes. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5187610/ /pubmed/28096576 http://dx.doi.org/10.4103/0970-9185.194770 Text en Copyright: © Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Elbaradey, Ghada Fouad Elshmaa, Nagat Sayed Hodeib, Hossam Role of edaravone in managemant of septic peritonitis |
title | Role of edaravone in managemant of septic peritonitis |
title_full | Role of edaravone in managemant of septic peritonitis |
title_fullStr | Role of edaravone in managemant of septic peritonitis |
title_full_unstemmed | Role of edaravone in managemant of septic peritonitis |
title_short | Role of edaravone in managemant of septic peritonitis |
title_sort | role of edaravone in managemant of septic peritonitis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187610/ https://www.ncbi.nlm.nih.gov/pubmed/28096576 http://dx.doi.org/10.4103/0970-9185.194770 |
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