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Intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries
BACKGROUND AND AIM: Preservative free tramadol has been used as an adjuvant to intrathecal bupivacaine. However, the effect of the addition of tramadol on intrathecal isobaric ropivacaine has never been studied. MATERIAL AND METHODS: This prospective, randomized, double-blind study was conducted in...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187613/ https://www.ncbi.nlm.nih.gov/pubmed/28096579 http://dx.doi.org/10.4103/0970-9185.173323 |
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author | Salhotra, Rashmi Mohta, Medha Agarwal, Deepti Sethi, Ashok K. |
author_facet | Salhotra, Rashmi Mohta, Medha Agarwal, Deepti Sethi, Ashok K. |
author_sort | Salhotra, Rashmi |
collection | PubMed |
description | BACKGROUND AND AIM: Preservative free tramadol has been used as an adjuvant to intrathecal bupivacaine. However, the effect of the addition of tramadol on intrathecal isobaric ropivacaine has never been studied. MATERIAL AND METHODS: This prospective, randomized, double-blind study was conducted in 50 adult male American Society of Anesthesiologists grade I or II patients, aged 18–60 years, being operated for unilateral femur fractures. An epidural catheter was inserted in L2-L3 interspace and subarachnoid block was given in L3-L4 space. The patients were randomized to receive 0.5 mL normal saline (group R) or 0.5 mL (25 mg) preservative free tramadol (group RT) with 2.5 mL of 0.75% intrathecal ropivacaine. Hemodynamic parameters, sensory level, motor block, sedation and side-effects were recorded. Statistical analysis was done using Student's t-test, Chi-square test, Fischer's exact test and repeated measures ANOVA. RESULTS: The time of sensory block onset was 9.2 ± 4.9 min and 8.6 ± 5.3 min (P = 0.714) in group R and group RT, respectively. The motor block onset was also comparable in both the groups (P = 0.112). The duration of sensory block was 147.2 ± 37.4 min in group R and 160.4 ± 40.9 min in group RT (P = 0.252). The median maximum block height achieved in both the groups was T6 and the time to achieve the maximum block was also comparable statistically (P = 0.301). CONCLUSION: The addition of intrathecal tramadol 25 mg to the isobaric ropivacaine does not alter the block characteristics produced by intrathecal ropivacaine alone. |
format | Online Article Text |
id | pubmed-5187613 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-51876132017-01-17 Intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries Salhotra, Rashmi Mohta, Medha Agarwal, Deepti Sethi, Ashok K. J Anaesthesiol Clin Pharmacol Original Article BACKGROUND AND AIM: Preservative free tramadol has been used as an adjuvant to intrathecal bupivacaine. However, the effect of the addition of tramadol on intrathecal isobaric ropivacaine has never been studied. MATERIAL AND METHODS: This prospective, randomized, double-blind study was conducted in 50 adult male American Society of Anesthesiologists grade I or II patients, aged 18–60 years, being operated for unilateral femur fractures. An epidural catheter was inserted in L2-L3 interspace and subarachnoid block was given in L3-L4 space. The patients were randomized to receive 0.5 mL normal saline (group R) or 0.5 mL (25 mg) preservative free tramadol (group RT) with 2.5 mL of 0.75% intrathecal ropivacaine. Hemodynamic parameters, sensory level, motor block, sedation and side-effects were recorded. Statistical analysis was done using Student's t-test, Chi-square test, Fischer's exact test and repeated measures ANOVA. RESULTS: The time of sensory block onset was 9.2 ± 4.9 min and 8.6 ± 5.3 min (P = 0.714) in group R and group RT, respectively. The motor block onset was also comparable in both the groups (P = 0.112). The duration of sensory block was 147.2 ± 37.4 min in group R and 160.4 ± 40.9 min in group RT (P = 0.252). The median maximum block height achieved in both the groups was T6 and the time to achieve the maximum block was also comparable statistically (P = 0.301). CONCLUSION: The addition of intrathecal tramadol 25 mg to the isobaric ropivacaine does not alter the block characteristics produced by intrathecal ropivacaine alone. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5187613/ /pubmed/28096579 http://dx.doi.org/10.4103/0970-9185.173323 Text en Copyright: © Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Salhotra, Rashmi Mohta, Medha Agarwal, Deepti Sethi, Ashok K. Intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries |
title | Intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries |
title_full | Intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries |
title_fullStr | Intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries |
title_full_unstemmed | Intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries |
title_short | Intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries |
title_sort | intrathecal ropivacaine with or without tramadol for lower limb orthopedic surgeries |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187613/ https://www.ncbi.nlm.nih.gov/pubmed/28096579 http://dx.doi.org/10.4103/0970-9185.173323 |
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