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Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy

BACKGROUND AND AIMS: Poorly managed acute postoperative pain may result in prolonged morbidity. Various pharmacotherapies have targeted this, but research on an ideal preemptive analgesic continues, taking into account drug-related side effects. Considering the better tolerability profile of tapenta...

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Autores principales: Yadav, Ghanshyam, Jain, Gaurav, Samprathi, Abhishek, Baghel, Annavi, Singh, Dinesh Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187615/
https://www.ncbi.nlm.nih.gov/pubmed/28096581
http://dx.doi.org/10.4103/0970-9185.168257
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author Yadav, Ghanshyam
Jain, Gaurav
Samprathi, Abhishek
Baghel, Annavi
Singh, Dinesh Kumar
author_facet Yadav, Ghanshyam
Jain, Gaurav
Samprathi, Abhishek
Baghel, Annavi
Singh, Dinesh Kumar
author_sort Yadav, Ghanshyam
collection PubMed
description BACKGROUND AND AIMS: Poorly managed acute postoperative pain may result in prolonged morbidity. Various pharmacotherapies have targeted this, but research on an ideal preemptive analgesic continues, taking into account drug-related side effects. Considering the better tolerability profile of tapentadol, we assessed its role as a preemptive analgesic in the reduction of postoperative analgesic requirements, after laparoscopic cholecystectomy. MATERIAL AND METHODS: In a prospective-double-blinded fashion, sixty patients posted for above surgery, were randomized to receive tablet tapentadol 75 mg (Group A) or starch tablets (Group B) orally, an hour before induction of general anesthesia. Perioperative analgesic requirement, time to first analgesia, pain, and sedation score were compared for first 24 h during the postoperative period and analyzed by one-way analysis of variance test. A P < 0.05 was considered significant. RESULTS: Sixty patients were analyzed. The perioperative analgesic requirement was significantly lower in Group A. Verbal numerical score was significantly lower in Group A at the time point, immediately after shifting the patient to the postanesthesia care unit. Ramsay sedation scores were similar between the groups. No major side effects were observed except for nausea and vomiting in 26 cases (10 in Group A, 16 in Group B). CONCLUSION: Single preemptive oral dose of tapentadol (75 mg) is effective in reducing perioperative analgesic requirements and acute postoperative pain, without added side effects. It could be an appropriate preemptive analgesic, subjected to future trials concentrating upon its dose-response effects.
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spelling pubmed-51876152017-01-17 Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy Yadav, Ghanshyam Jain, Gaurav Samprathi, Abhishek Baghel, Annavi Singh, Dinesh Kumar J Anaesthesiol Clin Pharmacol Original Article BACKGROUND AND AIMS: Poorly managed acute postoperative pain may result in prolonged morbidity. Various pharmacotherapies have targeted this, but research on an ideal preemptive analgesic continues, taking into account drug-related side effects. Considering the better tolerability profile of tapentadol, we assessed its role as a preemptive analgesic in the reduction of postoperative analgesic requirements, after laparoscopic cholecystectomy. MATERIAL AND METHODS: In a prospective-double-blinded fashion, sixty patients posted for above surgery, were randomized to receive tablet tapentadol 75 mg (Group A) or starch tablets (Group B) orally, an hour before induction of general anesthesia. Perioperative analgesic requirement, time to first analgesia, pain, and sedation score were compared for first 24 h during the postoperative period and analyzed by one-way analysis of variance test. A P < 0.05 was considered significant. RESULTS: Sixty patients were analyzed. The perioperative analgesic requirement was significantly lower in Group A. Verbal numerical score was significantly lower in Group A at the time point, immediately after shifting the patient to the postanesthesia care unit. Ramsay sedation scores were similar between the groups. No major side effects were observed except for nausea and vomiting in 26 cases (10 in Group A, 16 in Group B). CONCLUSION: Single preemptive oral dose of tapentadol (75 mg) is effective in reducing perioperative analgesic requirements and acute postoperative pain, without added side effects. It could be an appropriate preemptive analgesic, subjected to future trials concentrating upon its dose-response effects. Medknow Publications & Media Pvt Ltd 2016 /pmc/articles/PMC5187615/ /pubmed/28096581 http://dx.doi.org/10.4103/0970-9185.168257 Text en Copyright: © Journal of Anaesthesiology Clinical Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Original Article
Yadav, Ghanshyam
Jain, Gaurav
Samprathi, Abhishek
Baghel, Annavi
Singh, Dinesh Kumar
Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy
title Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy
title_full Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy
title_fullStr Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy
title_full_unstemmed Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy
title_short Role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy
title_sort role of preemptive tapentadol in reduction of postoperative analgesic requirements after laparoscopic cholecystectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187615/
https://www.ncbi.nlm.nih.gov/pubmed/28096581
http://dx.doi.org/10.4103/0970-9185.168257
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