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Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis
The scientific community still faces the challenge of developing strategies to cure HIV-1. One of these pursued strategies is the development of immunotherapeutic vaccines based on dendritic cells (DCs), pulsed with the virus, that aim to boost HIV-1 specific immune response. We aimed to review DCs-...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187785/ https://www.ncbi.nlm.nih.gov/pubmed/27898045 http://dx.doi.org/10.3390/ijms17121985 |
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author | Coelho, Antonio Victor Campos de Moura, Ronald Rodrigues Kamada, Anselmo Jiro da Silva, Ronaldo Celerino Guimarães, Rafael Lima Brandão, Lucas André Cavalcanti de Alencar, Luiz Cláudio Arraes Crovella, Sergio |
author_facet | Coelho, Antonio Victor Campos de Moura, Ronald Rodrigues Kamada, Anselmo Jiro da Silva, Ronaldo Celerino Guimarães, Rafael Lima Brandão, Lucas André Cavalcanti de Alencar, Luiz Cláudio Arraes Crovella, Sergio |
author_sort | Coelho, Antonio Victor Campos |
collection | PubMed |
description | The scientific community still faces the challenge of developing strategies to cure HIV-1. One of these pursued strategies is the development of immunotherapeutic vaccines based on dendritic cells (DCs), pulsed with the virus, that aim to boost HIV-1 specific immune response. We aimed to review DCs-based therapeutic vaccines reports and critically assess evidence to gain insights for the improvement of these strategies. We performed a systematic review, followed by meta-analysis and meta-regression, of clinical trial reports. Twelve studies were selected for meta-analysis. The experimental vaccines had low efficiency, with an overall success rate around 38% (95% confidence interval = 26.7%–51.3%). Protocols differed according to antigen choice, DC culture method, and doses, although multivariate analysis did not show an influence of any of them on overall success rate. The DC-based vaccines elicited at least some immunogenicity, that was sometimes associated with plasmatic viral load transient control. The protocols included both naïve and antiretroviral therapy (ART)-experienced individuals, and used different criteria for assessing vaccine efficacy. Although the vaccines did not work as expected, they are proof of concept that immune responses can be boosted against HIV-1. Protocol standardization and use of auxiliary approaches, such as latent HIV-1 reservoir activation and patient genomics are paramount for fine-tuning future HIV-1 cure strategies. |
format | Online Article Text |
id | pubmed-5187785 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51877852016-12-30 Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis Coelho, Antonio Victor Campos de Moura, Ronald Rodrigues Kamada, Anselmo Jiro da Silva, Ronaldo Celerino Guimarães, Rafael Lima Brandão, Lucas André Cavalcanti de Alencar, Luiz Cláudio Arraes Crovella, Sergio Int J Mol Sci Review The scientific community still faces the challenge of developing strategies to cure HIV-1. One of these pursued strategies is the development of immunotherapeutic vaccines based on dendritic cells (DCs), pulsed with the virus, that aim to boost HIV-1 specific immune response. We aimed to review DCs-based therapeutic vaccines reports and critically assess evidence to gain insights for the improvement of these strategies. We performed a systematic review, followed by meta-analysis and meta-regression, of clinical trial reports. Twelve studies were selected for meta-analysis. The experimental vaccines had low efficiency, with an overall success rate around 38% (95% confidence interval = 26.7%–51.3%). Protocols differed according to antigen choice, DC culture method, and doses, although multivariate analysis did not show an influence of any of them on overall success rate. The DC-based vaccines elicited at least some immunogenicity, that was sometimes associated with plasmatic viral load transient control. The protocols included both naïve and antiretroviral therapy (ART)-experienced individuals, and used different criteria for assessing vaccine efficacy. Although the vaccines did not work as expected, they are proof of concept that immune responses can be boosted against HIV-1. Protocol standardization and use of auxiliary approaches, such as latent HIV-1 reservoir activation and patient genomics are paramount for fine-tuning future HIV-1 cure strategies. MDPI 2016-11-26 /pmc/articles/PMC5187785/ /pubmed/27898045 http://dx.doi.org/10.3390/ijms17121985 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Coelho, Antonio Victor Campos de Moura, Ronald Rodrigues Kamada, Anselmo Jiro da Silva, Ronaldo Celerino Guimarães, Rafael Lima Brandão, Lucas André Cavalcanti de Alencar, Luiz Cláudio Arraes Crovella, Sergio Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis |
title | Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis |
title_full | Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis |
title_fullStr | Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis |
title_full_unstemmed | Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis |
title_short | Dendritic Cell-Based Immunotherapies to Fight HIV: How Far from a Success Story? A Systematic Review and Meta-Analysis |
title_sort | dendritic cell-based immunotherapies to fight hiv: how far from a success story? a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187785/ https://www.ncbi.nlm.nih.gov/pubmed/27898045 http://dx.doi.org/10.3390/ijms17121985 |
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