Exosomes as miRNA Carriers: Formation–Function–Future

Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing unde...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Xiaojie, Odenthal, Margarete, Fries, Jochen W. U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187828/
https://www.ncbi.nlm.nih.gov/pubmed/27918449
http://dx.doi.org/10.3390/ijms17122028
_version_ 1782486907082506240
author Yu, Xiaojie
Odenthal, Margarete
Fries, Jochen W. U.
author_facet Yu, Xiaojie
Odenthal, Margarete
Fries, Jochen W. U.
author_sort Yu, Xiaojie
collection PubMed
description Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes’ formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine.
format Online
Article
Text
id pubmed-5187828
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-51878282016-12-30 Exosomes as miRNA Carriers: Formation–Function–Future Yu, Xiaojie Odenthal, Margarete Fries, Jochen W. U. Int J Mol Sci Review Exosomes, which are one of the smallest extracellular vesicles released from cells, have been shown to carry different nucleic acids, including microRNAs (miRNAs). miRNAs significantly regulate cell growth and metabolism by posttranscriptional inhibition of gene expression. The rapidly changing understanding of exosomes’ formation and function in delivering miRNAs from cell to cell has prompted us to review current knowledge in exosomal miRNA secretion mechanisms as well as possible therapeutic applications for personalized medicine. MDPI 2016-12-02 /pmc/articles/PMC5187828/ /pubmed/27918449 http://dx.doi.org/10.3390/ijms17122028 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yu, Xiaojie
Odenthal, Margarete
Fries, Jochen W. U.
Exosomes as miRNA Carriers: Formation–Function–Future
title Exosomes as miRNA Carriers: Formation–Function–Future
title_full Exosomes as miRNA Carriers: Formation–Function–Future
title_fullStr Exosomes as miRNA Carriers: Formation–Function–Future
title_full_unstemmed Exosomes as miRNA Carriers: Formation–Function–Future
title_short Exosomes as miRNA Carriers: Formation–Function–Future
title_sort exosomes as mirna carriers: formation–function–future
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187828/
https://www.ncbi.nlm.nih.gov/pubmed/27918449
http://dx.doi.org/10.3390/ijms17122028
work_keys_str_mv AT yuxiaojie exosomesasmirnacarriersformationfunctionfuture
AT odenthalmargarete exosomesasmirnacarriersformationfunctionfuture
AT friesjochenwu exosomesasmirnacarriersformationfunctionfuture

Ejemplares similares