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Integrins in the Spotlight of Cancer

Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the Hallmarks of...

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Detalles Bibliográficos
Autores principales: Bianconi, Daniela, Unseld, Matthias, Prager, Gerald W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187837/
https://www.ncbi.nlm.nih.gov/pubmed/27929432
http://dx.doi.org/10.3390/ijms17122037
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author Bianconi, Daniela
Unseld, Matthias
Prager, Gerald W.
author_facet Bianconi, Daniela
Unseld, Matthias
Prager, Gerald W.
author_sort Bianconi, Daniela
collection PubMed
description Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the Hallmarks of Cancer. In this review, we will discuss the contribution of integrins to these hallmarks, including uncontrolled and limitless proliferation, invasion of tumor cells, promotion of tumor angiogenesis and evasion of apoptosis and resistance to growth suppressors, by highlighting the latest findings. Further on, given the paramount role of integrins in cancer, we will present novel strategies for integrin inhibition that are starting to emerge, promising a hopeful future regarding cancer treatment.
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spelling pubmed-51878372016-12-30 Integrins in the Spotlight of Cancer Bianconi, Daniela Unseld, Matthias Prager, Gerald W. Int J Mol Sci Review Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the Hallmarks of Cancer. In this review, we will discuss the contribution of integrins to these hallmarks, including uncontrolled and limitless proliferation, invasion of tumor cells, promotion of tumor angiogenesis and evasion of apoptosis and resistance to growth suppressors, by highlighting the latest findings. Further on, given the paramount role of integrins in cancer, we will present novel strategies for integrin inhibition that are starting to emerge, promising a hopeful future regarding cancer treatment. MDPI 2016-12-06 /pmc/articles/PMC5187837/ /pubmed/27929432 http://dx.doi.org/10.3390/ijms17122037 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bianconi, Daniela
Unseld, Matthias
Prager, Gerald W.
Integrins in the Spotlight of Cancer
title Integrins in the Spotlight of Cancer
title_full Integrins in the Spotlight of Cancer
title_fullStr Integrins in the Spotlight of Cancer
title_full_unstemmed Integrins in the Spotlight of Cancer
title_short Integrins in the Spotlight of Cancer
title_sort integrins in the spotlight of cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187837/
https://www.ncbi.nlm.nih.gov/pubmed/27929432
http://dx.doi.org/10.3390/ijms17122037
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