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Integrins in the Spotlight of Cancer
Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the Hallmarks of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187837/ https://www.ncbi.nlm.nih.gov/pubmed/27929432 http://dx.doi.org/10.3390/ijms17122037 |
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author | Bianconi, Daniela Unseld, Matthias Prager, Gerald W. |
author_facet | Bianconi, Daniela Unseld, Matthias Prager, Gerald W. |
author_sort | Bianconi, Daniela |
collection | PubMed |
description | Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the Hallmarks of Cancer. In this review, we will discuss the contribution of integrins to these hallmarks, including uncontrolled and limitless proliferation, invasion of tumor cells, promotion of tumor angiogenesis and evasion of apoptosis and resistance to growth suppressors, by highlighting the latest findings. Further on, given the paramount role of integrins in cancer, we will present novel strategies for integrin inhibition that are starting to emerge, promising a hopeful future regarding cancer treatment. |
format | Online Article Text |
id | pubmed-5187837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51878372016-12-30 Integrins in the Spotlight of Cancer Bianconi, Daniela Unseld, Matthias Prager, Gerald W. Int J Mol Sci Review Integrins are heterodimeric cell surface receptors that bind to different extracellular ligands depending on their composition and regulate all processes which enable multicellular life. In cancer, integrins trigger and play key roles in all the features that were once described as the Hallmarks of Cancer. In this review, we will discuss the contribution of integrins to these hallmarks, including uncontrolled and limitless proliferation, invasion of tumor cells, promotion of tumor angiogenesis and evasion of apoptosis and resistance to growth suppressors, by highlighting the latest findings. Further on, given the paramount role of integrins in cancer, we will present novel strategies for integrin inhibition that are starting to emerge, promising a hopeful future regarding cancer treatment. MDPI 2016-12-06 /pmc/articles/PMC5187837/ /pubmed/27929432 http://dx.doi.org/10.3390/ijms17122037 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bianconi, Daniela Unseld, Matthias Prager, Gerald W. Integrins in the Spotlight of Cancer |
title | Integrins in the Spotlight of Cancer |
title_full | Integrins in the Spotlight of Cancer |
title_fullStr | Integrins in the Spotlight of Cancer |
title_full_unstemmed | Integrins in the Spotlight of Cancer |
title_short | Integrins in the Spotlight of Cancer |
title_sort | integrins in the spotlight of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187837/ https://www.ncbi.nlm.nih.gov/pubmed/27929432 http://dx.doi.org/10.3390/ijms17122037 |
work_keys_str_mv | AT bianconidaniela integrinsinthespotlightofcancer AT unseldmatthias integrinsinthespotlightofcancer AT pragergeraldw integrinsinthespotlightofcancer |