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Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis

Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP se...

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Autores principales: Dumnicka, Paulina, Sporek, Mateusz, Mazur-Laskowska, Małgorzata, Ceranowicz, Piotr, Kuźniewski, Marek, Drożdż, Ryszard, Ambroży, Tadeusz, Olszanecki, Rafał, Kuśnierz-Cabala, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187838/
https://www.ncbi.nlm.nih.gov/pubmed/27929426
http://dx.doi.org/10.3390/ijms17122038
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author Dumnicka, Paulina
Sporek, Mateusz
Mazur-Laskowska, Małgorzata
Ceranowicz, Piotr
Kuźniewski, Marek
Drożdż, Ryszard
Ambroży, Tadeusz
Olszanecki, Rafał
Kuśnierz-Cabala, Beata
author_facet Dumnicka, Paulina
Sporek, Mateusz
Mazur-Laskowska, Małgorzata
Ceranowicz, Piotr
Kuźniewski, Marek
Drożdż, Ryszard
Ambroży, Tadeusz
Olszanecki, Rafał
Kuśnierz-Cabala, Beata
author_sort Dumnicka, Paulina
collection PubMed
description Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP severity. Adult patients (66) with AP were recruited, including 46 with mild (MAP), 15 with moderately-severe (MSAP) and 5 with severe AP (SAP). Serum and urine samples were collected twice. Serum sFlt-1 was measured with automated electrochemiluminescence immunoassay. Serum concentrations of sFlt-1 were significantly higher in patients with MSAP and SAP as compared to MAP. SAP patients had the highest concentrations. At 24 and 48 h, sFlt-1 positively correlated with inflammatory markers (leukocyte count, C-reactive protein), kidney function (creatinine, urea, cystatin C, serum and urine neutrophil gelatinase-associated lipocalin, urine albumin/creatinine ratio), D-dimer and angiopoietin-2. sFlt-1 positively correlated with the bedside index of severity in AP (BISAP) score and the duration of hospital stay. Serum sFlt-1 above 139 pg/mL predicted more severe AP (MSAP + SAP). In the early phase of AP, sFlt-1 is positively associated with the severity of AP and predicts organ failure, in particular kidney failure. Serum sFlt-1 may be a practical way to improve early assessment of AP severity.
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spelling pubmed-51878382016-12-30 Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis Dumnicka, Paulina Sporek, Mateusz Mazur-Laskowska, Małgorzata Ceranowicz, Piotr Kuźniewski, Marek Drożdż, Ryszard Ambroży, Tadeusz Olszanecki, Rafał Kuśnierz-Cabala, Beata Int J Mol Sci Article Organ failure is the most important determinant of the severity of acute pancreatitis (AP). Soluble fms-like tyrosine kinase 1 (sFlt-1) is positively associated with organ failure in sepsis. Our aim was to evaluate the diagnostic utility of automated sFlt-1 measurements for early prediction of AP severity. Adult patients (66) with AP were recruited, including 46 with mild (MAP), 15 with moderately-severe (MSAP) and 5 with severe AP (SAP). Serum and urine samples were collected twice. Serum sFlt-1 was measured with automated electrochemiluminescence immunoassay. Serum concentrations of sFlt-1 were significantly higher in patients with MSAP and SAP as compared to MAP. SAP patients had the highest concentrations. At 24 and 48 h, sFlt-1 positively correlated with inflammatory markers (leukocyte count, C-reactive protein), kidney function (creatinine, urea, cystatin C, serum and urine neutrophil gelatinase-associated lipocalin, urine albumin/creatinine ratio), D-dimer and angiopoietin-2. sFlt-1 positively correlated with the bedside index of severity in AP (BISAP) score and the duration of hospital stay. Serum sFlt-1 above 139 pg/mL predicted more severe AP (MSAP + SAP). In the early phase of AP, sFlt-1 is positively associated with the severity of AP and predicts organ failure, in particular kidney failure. Serum sFlt-1 may be a practical way to improve early assessment of AP severity. MDPI 2016-12-06 /pmc/articles/PMC5187838/ /pubmed/27929426 http://dx.doi.org/10.3390/ijms17122038 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dumnicka, Paulina
Sporek, Mateusz
Mazur-Laskowska, Małgorzata
Ceranowicz, Piotr
Kuźniewski, Marek
Drożdż, Ryszard
Ambroży, Tadeusz
Olszanecki, Rafał
Kuśnierz-Cabala, Beata
Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis
title Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis
title_full Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis
title_fullStr Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis
title_full_unstemmed Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis
title_short Serum Soluble Fms-Like Tyrosine Kinase 1 (sFlt-1) Predicts the Severity of Acute Pancreatitis
title_sort serum soluble fms-like tyrosine kinase 1 (sflt-1) predicts the severity of acute pancreatitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187838/
https://www.ncbi.nlm.nih.gov/pubmed/27929426
http://dx.doi.org/10.3390/ijms17122038
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