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Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis

Store-Operated Calcium Entry (SOCE) is a universal calcium (Ca(2+)) influx mechanism expressed by several different cell types. It is now known that Stromal Interaction Molecule (STIM), the Ca(2+) sensor of the intracellular compartments, together with Orai and Transient Receptor Potential Canonical...

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Autores principales: Di Buduo, Christian A., Balduini, Alessandra, Moccia, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187855/
https://www.ncbi.nlm.nih.gov/pubmed/27941645
http://dx.doi.org/10.3390/ijms17122055
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author Di Buduo, Christian A.
Balduini, Alessandra
Moccia, Francesco
author_facet Di Buduo, Christian A.
Balduini, Alessandra
Moccia, Francesco
author_sort Di Buduo, Christian A.
collection PubMed
description Store-Operated Calcium Entry (SOCE) is a universal calcium (Ca(2+)) influx mechanism expressed by several different cell types. It is now known that Stromal Interaction Molecule (STIM), the Ca(2+) sensor of the intracellular compartments, together with Orai and Transient Receptor Potential Canonical (TRPC), the subunits of Ca(2+) permeable channels on the plasma membrane, cooperate in regulating multiple cellular functions as diverse as proliferation, differentiation, migration, gene expression, and many others, depending on the cell type. In particular, a growing body of evidences suggests that a tight control of SOCE expression and function is achieved by megakaryocytes along their route from hematopoietic stem cells to platelet production. This review attempts to provide an overview about the SOCE dynamics in megakaryocyte development, with a focus on most recent findings related to its involvement in physiological and pathological thrombopoiesis.
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spelling pubmed-51878552016-12-30 Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis Di Buduo, Christian A. Balduini, Alessandra Moccia, Francesco Int J Mol Sci Review Store-Operated Calcium Entry (SOCE) is a universal calcium (Ca(2+)) influx mechanism expressed by several different cell types. It is now known that Stromal Interaction Molecule (STIM), the Ca(2+) sensor of the intracellular compartments, together with Orai and Transient Receptor Potential Canonical (TRPC), the subunits of Ca(2+) permeable channels on the plasma membrane, cooperate in regulating multiple cellular functions as diverse as proliferation, differentiation, migration, gene expression, and many others, depending on the cell type. In particular, a growing body of evidences suggests that a tight control of SOCE expression and function is achieved by megakaryocytes along their route from hematopoietic stem cells to platelet production. This review attempts to provide an overview about the SOCE dynamics in megakaryocyte development, with a focus on most recent findings related to its involvement in physiological and pathological thrombopoiesis. MDPI 2016-12-08 /pmc/articles/PMC5187855/ /pubmed/27941645 http://dx.doi.org/10.3390/ijms17122055 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Buduo, Christian A.
Balduini, Alessandra
Moccia, Francesco
Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis
title Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis
title_full Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis
title_fullStr Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis
title_full_unstemmed Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis
title_short Pathophysiological Significance of Store-Operated Calcium Entry in Megakaryocyte Function: Opening New Paths for Understanding the Role of Calcium in Thrombopoiesis
title_sort pathophysiological significance of store-operated calcium entry in megakaryocyte function: opening new paths for understanding the role of calcium in thrombopoiesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187855/
https://www.ncbi.nlm.nih.gov/pubmed/27941645
http://dx.doi.org/10.3390/ijms17122055
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