Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases

Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-i...

Descripción completa

Detalles Bibliográficos
Autores principales: Houh, Youn Kyung, Kim, Kyung Eun, Park, Hyun Jeong, Cho, Daeho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187859/
https://www.ncbi.nlm.nih.gov/pubmed/27941650
http://dx.doi.org/10.3390/ijms17122059
Descripción
Sumario:Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.

Ejemplares similares