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Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)

Physical activity and the ingestion of dietary fiber are non-drug alternatives commonly used as adjuvants to glycemic control in diabetic individuals. Among these fibers, we can highlight beta-glucans. However, few studies have compared isolated and synergic effects of physical exercise and beta-glu...

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Autores principales: Andrade, Eric Francelino, Lima, Andressa Ribeiro Veiga, Nunes, Ingrid Edwiges, Orlando, Débora Ribeiro, Gondim, Paula Novato, Zangeronimo, Márcio Gilberto, Alves, Fernando Henrique Ferrari, Pereira, Luciano José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188447/
https://www.ncbi.nlm.nih.gov/pubmed/27999319
http://dx.doi.org/10.3390/nu8120792
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author Andrade, Eric Francelino
Lima, Andressa Ribeiro Veiga
Nunes, Ingrid Edwiges
Orlando, Débora Ribeiro
Gondim, Paula Novato
Zangeronimo, Márcio Gilberto
Alves, Fernando Henrique Ferrari
Pereira, Luciano José
author_facet Andrade, Eric Francelino
Lima, Andressa Ribeiro Veiga
Nunes, Ingrid Edwiges
Orlando, Débora Ribeiro
Gondim, Paula Novato
Zangeronimo, Márcio Gilberto
Alves, Fernando Henrique Ferrari
Pereira, Luciano José
author_sort Andrade, Eric Francelino
collection PubMed
description Physical activity and the ingestion of dietary fiber are non-drug alternatives commonly used as adjuvants to glycemic control in diabetic individuals. Among these fibers, we can highlight beta-glucans. However, few studies have compared isolated and synergic effects of physical exercise and beta-glucan ingestion, especially in type 2 diabetic rats. Therefore, we evaluated the effects beta-glucan (Saccharomyces cerevisiae) consumption, associated or not to exercise, on metabolic parameters of diabetic Wistar rats. The diabetes mellitus (DM) was induced by high-fat diet (HFD) associated with a low dose of streptozotocin (STZ—35 mg/kg). Trained groups were submitted to eight weeks of exercise in aquatic environment. In the last 28 days of experiment, animals received 30 mg/kg/day of beta-glucan by gavage. Isolated use of beta-glucan decreased glucose levels in fasting, Glycated hemoglobin (HbA1c), triglycerides (TAG), total cholesterol (TC), low-density lipoprotein (LDL-C), the atherogenic index of plasma. Exercise alone also decreased blood glucose levels, HbA1c, and renal lesions. An additive effect for reducing the atherogenic index of plasma and renal lesions was observed when both treatments were combined. It was concluded that both beta-glucan and exercise improved metabolic parameters in type 2 (HFD/STZ) diabetic rats.
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spelling pubmed-51884472017-01-03 Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ) Andrade, Eric Francelino Lima, Andressa Ribeiro Veiga Nunes, Ingrid Edwiges Orlando, Débora Ribeiro Gondim, Paula Novato Zangeronimo, Márcio Gilberto Alves, Fernando Henrique Ferrari Pereira, Luciano José Nutrients Article Physical activity and the ingestion of dietary fiber are non-drug alternatives commonly used as adjuvants to glycemic control in diabetic individuals. Among these fibers, we can highlight beta-glucans. However, few studies have compared isolated and synergic effects of physical exercise and beta-glucan ingestion, especially in type 2 diabetic rats. Therefore, we evaluated the effects beta-glucan (Saccharomyces cerevisiae) consumption, associated or not to exercise, on metabolic parameters of diabetic Wistar rats. The diabetes mellitus (DM) was induced by high-fat diet (HFD) associated with a low dose of streptozotocin (STZ—35 mg/kg). Trained groups were submitted to eight weeks of exercise in aquatic environment. In the last 28 days of experiment, animals received 30 mg/kg/day of beta-glucan by gavage. Isolated use of beta-glucan decreased glucose levels in fasting, Glycated hemoglobin (HbA1c), triglycerides (TAG), total cholesterol (TC), low-density lipoprotein (LDL-C), the atherogenic index of plasma. Exercise alone also decreased blood glucose levels, HbA1c, and renal lesions. An additive effect for reducing the atherogenic index of plasma and renal lesions was observed when both treatments were combined. It was concluded that both beta-glucan and exercise improved metabolic parameters in type 2 (HFD/STZ) diabetic rats. MDPI 2016-12-17 /pmc/articles/PMC5188447/ /pubmed/27999319 http://dx.doi.org/10.3390/nu8120792 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Andrade, Eric Francelino
Lima, Andressa Ribeiro Veiga
Nunes, Ingrid Edwiges
Orlando, Débora Ribeiro
Gondim, Paula Novato
Zangeronimo, Márcio Gilberto
Alves, Fernando Henrique Ferrari
Pereira, Luciano José
Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)
title Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)
title_full Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)
title_fullStr Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)
title_full_unstemmed Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)
title_short Exercise and Beta-Glucan Consumption (Saccharomyces cerevisiae) Improve the Metabolic Profile and Reduce the Atherogenic Index in Type 2 Diabetic Rats (HFD/STZ)
title_sort exercise and beta-glucan consumption (saccharomyces cerevisiae) improve the metabolic profile and reduce the atherogenic index in type 2 diabetic rats (hfd/stz)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188447/
https://www.ncbi.nlm.nih.gov/pubmed/27999319
http://dx.doi.org/10.3390/nu8120792
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