Cargando…

A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women

This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were...

Descripción completa

Detalles Bibliográficos
Autores principales: Choi, Rihwa, Choi, Sunkyu, Lim, Yaeji, Cho, Yoon Young, Kim, Hye Jeong, Kim, Sun Wook, Chung, Jae Hoon, Oh, Soo-young, Lee, Soo-Youn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188452/
https://www.ncbi.nlm.nih.gov/pubmed/27941633
http://dx.doi.org/10.3390/nu8120797
_version_ 1782487037324034048
author Choi, Rihwa
Choi, Sunkyu
Lim, Yaeji
Cho, Yoon Young
Kim, Hye Jeong
Kim, Sun Wook
Chung, Jae Hoon
Oh, Soo-young
Lee, Soo-Youn
author_facet Choi, Rihwa
Choi, Sunkyu
Lim, Yaeji
Cho, Yoon Young
Kim, Hye Jeong
Kim, Sun Wook
Chung, Jae Hoon
Oh, Soo-young
Lee, Soo-Youn
author_sort Choi, Rihwa
collection PubMed
description This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were compared with those of previous studies in other ethnic groups. We investigated the association between MMA and homocysteine status with pregnancy and neonatal events: gestational diabetes, preeclampsia, gestational age at delivery, preterm birth, small for gestational age, neonatal birth weight, and congenital abnormalities. The median (range) MMA level was 0.142 (0.063–0.446) µmol/L and homocysteine level was 10.6 (4.4–38.0) µmol/L in pregnant women. MMA levels were significantly higher in the third trimester than during other trimesters (p < 0.05), while homocysteine levels were not. No significant association was observed between MMA or homocysteine levels and any of the maternal or neonatal outcomes examined. Future studies are needed to assess the associations among maternal serum concentrations of MMA and homocysteine, and maternal and neonatal outcomes.
format Online
Article
Text
id pubmed-5188452
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-51884522017-01-03 A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women Choi, Rihwa Choi, Sunkyu Lim, Yaeji Cho, Yoon Young Kim, Hye Jeong Kim, Sun Wook Chung, Jae Hoon Oh, Soo-young Lee, Soo-Youn Nutrients Article This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were compared with those of previous studies in other ethnic groups. We investigated the association between MMA and homocysteine status with pregnancy and neonatal events: gestational diabetes, preeclampsia, gestational age at delivery, preterm birth, small for gestational age, neonatal birth weight, and congenital abnormalities. The median (range) MMA level was 0.142 (0.063–0.446) µmol/L and homocysteine level was 10.6 (4.4–38.0) µmol/L in pregnant women. MMA levels were significantly higher in the third trimester than during other trimesters (p < 0.05), while homocysteine levels were not. No significant association was observed between MMA or homocysteine levels and any of the maternal or neonatal outcomes examined. Future studies are needed to assess the associations among maternal serum concentrations of MMA and homocysteine, and maternal and neonatal outcomes. MDPI 2016-12-08 /pmc/articles/PMC5188452/ /pubmed/27941633 http://dx.doi.org/10.3390/nu8120797 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Rihwa
Choi, Sunkyu
Lim, Yaeji
Cho, Yoon Young
Kim, Hye Jeong
Kim, Sun Wook
Chung, Jae Hoon
Oh, Soo-young
Lee, Soo-Youn
A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women
title A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women
title_full A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women
title_fullStr A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women
title_full_unstemmed A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women
title_short A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women
title_sort prospective study on serum methylmalonic acid and homocysteine in pregnant women
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188452/
https://www.ncbi.nlm.nih.gov/pubmed/27941633
http://dx.doi.org/10.3390/nu8120797
work_keys_str_mv AT choirihwa aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT choisunkyu aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT limyaeji aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT choyoonyoung aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT kimhyejeong aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT kimsunwook aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT chungjaehoon aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT ohsooyoung aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT leesooyoun aprospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT choirihwa prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT choisunkyu prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT limyaeji prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT choyoonyoung prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT kimhyejeong prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT kimsunwook prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT chungjaehoon prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT ohsooyoung prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen
AT leesooyoun prospectivestudyonserummethylmalonicacidandhomocysteineinpregnantwomen