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A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women
This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188452/ https://www.ncbi.nlm.nih.gov/pubmed/27941633 http://dx.doi.org/10.3390/nu8120797 |
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author | Choi, Rihwa Choi, Sunkyu Lim, Yaeji Cho, Yoon Young Kim, Hye Jeong Kim, Sun Wook Chung, Jae Hoon Oh, Soo-young Lee, Soo-Youn |
author_facet | Choi, Rihwa Choi, Sunkyu Lim, Yaeji Cho, Yoon Young Kim, Hye Jeong Kim, Sun Wook Chung, Jae Hoon Oh, Soo-young Lee, Soo-Youn |
author_sort | Choi, Rihwa |
collection | PubMed |
description | This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were compared with those of previous studies in other ethnic groups. We investigated the association between MMA and homocysteine status with pregnancy and neonatal events: gestational diabetes, preeclampsia, gestational age at delivery, preterm birth, small for gestational age, neonatal birth weight, and congenital abnormalities. The median (range) MMA level was 0.142 (0.063–0.446) µmol/L and homocysteine level was 10.6 (4.4–38.0) µmol/L in pregnant women. MMA levels were significantly higher in the third trimester than during other trimesters (p < 0.05), while homocysteine levels were not. No significant association was observed between MMA or homocysteine levels and any of the maternal or neonatal outcomes examined. Future studies are needed to assess the associations among maternal serum concentrations of MMA and homocysteine, and maternal and neonatal outcomes. |
format | Online Article Text |
id | pubmed-5188452 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51884522017-01-03 A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women Choi, Rihwa Choi, Sunkyu Lim, Yaeji Cho, Yoon Young Kim, Hye Jeong Kim, Sun Wook Chung, Jae Hoon Oh, Soo-young Lee, Soo-Youn Nutrients Article This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were compared with those of previous studies in other ethnic groups. We investigated the association between MMA and homocysteine status with pregnancy and neonatal events: gestational diabetes, preeclampsia, gestational age at delivery, preterm birth, small for gestational age, neonatal birth weight, and congenital abnormalities. The median (range) MMA level was 0.142 (0.063–0.446) µmol/L and homocysteine level was 10.6 (4.4–38.0) µmol/L in pregnant women. MMA levels were significantly higher in the third trimester than during other trimesters (p < 0.05), while homocysteine levels were not. No significant association was observed between MMA or homocysteine levels and any of the maternal or neonatal outcomes examined. Future studies are needed to assess the associations among maternal serum concentrations of MMA and homocysteine, and maternal and neonatal outcomes. MDPI 2016-12-08 /pmc/articles/PMC5188452/ /pubmed/27941633 http://dx.doi.org/10.3390/nu8120797 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Choi, Rihwa Choi, Sunkyu Lim, Yaeji Cho, Yoon Young Kim, Hye Jeong Kim, Sun Wook Chung, Jae Hoon Oh, Soo-young Lee, Soo-Youn A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women |
title | A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women |
title_full | A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women |
title_fullStr | A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women |
title_full_unstemmed | A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women |
title_short | A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women |
title_sort | prospective study on serum methylmalonic acid and homocysteine in pregnant women |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188452/ https://www.ncbi.nlm.nih.gov/pubmed/27941633 http://dx.doi.org/10.3390/nu8120797 |
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