Cargando…
Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
Background: Describing vitamin D status and its predictors in various populations is important in order to target public health measures. Objectives: To describe the status and predictors of vitamin D status in healthy Nepalese mothers and infants. Methods: 500 randomly selected Nepalese mother and...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188478/ https://www.ncbi.nlm.nih.gov/pubmed/28009810 http://dx.doi.org/10.3390/nu8120825 |
_version_ | 1782487043371171840 |
---|---|
author | Haugen, Johanne Ulak, Manjeswori Chandyo, Ram K. Henjum, Sigrun Thorne-Lyman, Andrew L. Ueland, Per Magne Midtun, Øivind Shrestha, Prakash S. Strand, Tor A. |
author_facet | Haugen, Johanne Ulak, Manjeswori Chandyo, Ram K. Henjum, Sigrun Thorne-Lyman, Andrew L. Ueland, Per Magne Midtun, Øivind Shrestha, Prakash S. Strand, Tor A. |
author_sort | Haugen, Johanne |
collection | PubMed |
description | Background: Describing vitamin D status and its predictors in various populations is important in order to target public health measures. Objectives: To describe the status and predictors of vitamin D status in healthy Nepalese mothers and infants. Methods: 500 randomly selected Nepalese mother and infant pairs were included in a cross-sectional study. Plasma 25(OH)D concentrations were measured by LC-MS/MS and multiple linear regression analyses were used to identify predictors of vitamin D status. Results: Among the infants, the prevalence of vitamin D insufficiency (25(OH)D <50 nmol/L) and deficiency (<30 nmol/L) were 3.6% and 0.6%, respectively, in contrast to 59.8% and 14.0% among their mothers. Infant 25(OH)D concentrations were negatively associated with infant age and positively associated with maternal vitamin D status and body mass index (BMI), explaining 22% of the variability in 25(OH)D concentration. Global solar radiation, maternal age and BMI predicted maternal 25(OH)D concentration, explaining 9.7% of its variability. Conclusion: Age and maternal vitamin D status are the main predictors of vitamin D status in infants in Bhaktapur, Nepal, who have adequate vitamin D status despite poor vitamin D status in their mothers. |
format | Online Article Text |
id | pubmed-5188478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51884782017-01-03 Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers Haugen, Johanne Ulak, Manjeswori Chandyo, Ram K. Henjum, Sigrun Thorne-Lyman, Andrew L. Ueland, Per Magne Midtun, Øivind Shrestha, Prakash S. Strand, Tor A. Nutrients Article Background: Describing vitamin D status and its predictors in various populations is important in order to target public health measures. Objectives: To describe the status and predictors of vitamin D status in healthy Nepalese mothers and infants. Methods: 500 randomly selected Nepalese mother and infant pairs were included in a cross-sectional study. Plasma 25(OH)D concentrations were measured by LC-MS/MS and multiple linear regression analyses were used to identify predictors of vitamin D status. Results: Among the infants, the prevalence of vitamin D insufficiency (25(OH)D <50 nmol/L) and deficiency (<30 nmol/L) were 3.6% and 0.6%, respectively, in contrast to 59.8% and 14.0% among their mothers. Infant 25(OH)D concentrations were negatively associated with infant age and positively associated with maternal vitamin D status and body mass index (BMI), explaining 22% of the variability in 25(OH)D concentration. Global solar radiation, maternal age and BMI predicted maternal 25(OH)D concentration, explaining 9.7% of its variability. Conclusion: Age and maternal vitamin D status are the main predictors of vitamin D status in infants in Bhaktapur, Nepal, who have adequate vitamin D status despite poor vitamin D status in their mothers. MDPI 2016-12-21 /pmc/articles/PMC5188478/ /pubmed/28009810 http://dx.doi.org/10.3390/nu8120825 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Haugen, Johanne Ulak, Manjeswori Chandyo, Ram K. Henjum, Sigrun Thorne-Lyman, Andrew L. Ueland, Per Magne Midtun, Øivind Shrestha, Prakash S. Strand, Tor A. Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers |
title | Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers |
title_full | Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers |
title_fullStr | Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers |
title_full_unstemmed | Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers |
title_short | Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers |
title_sort | low prevalence of vitamin d insufficiency among nepalese infants despite high prevalence of vitamin d insufficiency among their mothers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188478/ https://www.ncbi.nlm.nih.gov/pubmed/28009810 http://dx.doi.org/10.3390/nu8120825 |
work_keys_str_mv | AT haugenjohanne lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers AT ulakmanjeswori lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers AT chandyoramk lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers AT henjumsigrun lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers AT thornelymanandrewl lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers AT uelandpermagne lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers AT midtunøivind lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers AT shresthaprakashs lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers AT strandtora lowprevalenceofvitamindinsufficiencyamongnepaleseinfantsdespitehighprevalenceofvitamindinsufficiencyamongtheirmothers |