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Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers

Background: Describing vitamin D status and its predictors in various populations is important in order to target public health measures. Objectives: To describe the status and predictors of vitamin D status in healthy Nepalese mothers and infants. Methods: 500 randomly selected Nepalese mother and...

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Autores principales: Haugen, Johanne, Ulak, Manjeswori, Chandyo, Ram K., Henjum, Sigrun, Thorne-Lyman, Andrew L., Ueland, Per Magne, Midtun, Øivind, Shrestha, Prakash S., Strand, Tor A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188478/
https://www.ncbi.nlm.nih.gov/pubmed/28009810
http://dx.doi.org/10.3390/nu8120825
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author Haugen, Johanne
Ulak, Manjeswori
Chandyo, Ram K.
Henjum, Sigrun
Thorne-Lyman, Andrew L.
Ueland, Per Magne
Midtun, Øivind
Shrestha, Prakash S.
Strand, Tor A.
author_facet Haugen, Johanne
Ulak, Manjeswori
Chandyo, Ram K.
Henjum, Sigrun
Thorne-Lyman, Andrew L.
Ueland, Per Magne
Midtun, Øivind
Shrestha, Prakash S.
Strand, Tor A.
author_sort Haugen, Johanne
collection PubMed
description Background: Describing vitamin D status and its predictors in various populations is important in order to target public health measures. Objectives: To describe the status and predictors of vitamin D status in healthy Nepalese mothers and infants. Methods: 500 randomly selected Nepalese mother and infant pairs were included in a cross-sectional study. Plasma 25(OH)D concentrations were measured by LC-MS/MS and multiple linear regression analyses were used to identify predictors of vitamin D status. Results: Among the infants, the prevalence of vitamin D insufficiency (25(OH)D <50 nmol/L) and deficiency (<30 nmol/L) were 3.6% and 0.6%, respectively, in contrast to 59.8% and 14.0% among their mothers. Infant 25(OH)D concentrations were negatively associated with infant age and positively associated with maternal vitamin D status and body mass index (BMI), explaining 22% of the variability in 25(OH)D concentration. Global solar radiation, maternal age and BMI predicted maternal 25(OH)D concentration, explaining 9.7% of its variability. Conclusion: Age and maternal vitamin D status are the main predictors of vitamin D status in infants in Bhaktapur, Nepal, who have adequate vitamin D status despite poor vitamin D status in their mothers.
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spelling pubmed-51884782017-01-03 Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers Haugen, Johanne Ulak, Manjeswori Chandyo, Ram K. Henjum, Sigrun Thorne-Lyman, Andrew L. Ueland, Per Magne Midtun, Øivind Shrestha, Prakash S. Strand, Tor A. Nutrients Article Background: Describing vitamin D status and its predictors in various populations is important in order to target public health measures. Objectives: To describe the status and predictors of vitamin D status in healthy Nepalese mothers and infants. Methods: 500 randomly selected Nepalese mother and infant pairs were included in a cross-sectional study. Plasma 25(OH)D concentrations were measured by LC-MS/MS and multiple linear regression analyses were used to identify predictors of vitamin D status. Results: Among the infants, the prevalence of vitamin D insufficiency (25(OH)D <50 nmol/L) and deficiency (<30 nmol/L) were 3.6% and 0.6%, respectively, in contrast to 59.8% and 14.0% among their mothers. Infant 25(OH)D concentrations were negatively associated with infant age and positively associated with maternal vitamin D status and body mass index (BMI), explaining 22% of the variability in 25(OH)D concentration. Global solar radiation, maternal age and BMI predicted maternal 25(OH)D concentration, explaining 9.7% of its variability. Conclusion: Age and maternal vitamin D status are the main predictors of vitamin D status in infants in Bhaktapur, Nepal, who have adequate vitamin D status despite poor vitamin D status in their mothers. MDPI 2016-12-21 /pmc/articles/PMC5188478/ /pubmed/28009810 http://dx.doi.org/10.3390/nu8120825 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Haugen, Johanne
Ulak, Manjeswori
Chandyo, Ram K.
Henjum, Sigrun
Thorne-Lyman, Andrew L.
Ueland, Per Magne
Midtun, Øivind
Shrestha, Prakash S.
Strand, Tor A.
Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
title Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
title_full Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
title_fullStr Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
title_full_unstemmed Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
title_short Low Prevalence of Vitamin D Insufficiency among Nepalese Infants Despite High Prevalence of Vitamin D Insufficiency among Their Mothers
title_sort low prevalence of vitamin d insufficiency among nepalese infants despite high prevalence of vitamin d insufficiency among their mothers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5188478/
https://www.ncbi.nlm.nih.gov/pubmed/28009810
http://dx.doi.org/10.3390/nu8120825
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