Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ

Certain mutant Alzheimer's amyloid-β (Aβ) peptides (that is, Dutch mutant APP(E693Q)) form complexes with gangliosides (GAβ). These mutant Aβ peptides may also undergo accelerated aggregation and accumulation upon exposure to GM2 and GM3. We hypothesized that increasing β-hexosaminidase (β-hex)...

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Detalles Bibliográficos
Autores principales: Knight, E M, Williams, H N, Stevens, A C, Kim, S H, Kottwitz, J C, Morant, A D, Steele, J W, Klein, W L, Yanagisawa, K, Boyd, R E, Lockhart, D J, Sjoberg, E R, Ehrlich, M E, Wustman, B A, Gandy, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Immediate Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189927/
https://www.ncbi.nlm.nih.gov/pubmed/25349165
http://dx.doi.org/10.1038/mp.2014.135

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