Non-human Primate Schlafen11 Inhibits Production of Both Host and Viral Proteins

Schlafen11 (encoded by the SLFN11 gene) has been shown to inhibit the accumulation of HIV-1 proteins. We show that the SLFN11 gene is under positive selection in simian primates and is species-specific in its activity against HIV-1. The activity of human Schlafen11 is relatively weak compared to tha...

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Detalles Bibliográficos
Autores principales: Stabell, Alex C., Hawkins, John, Li, Manqing, Gao, Xia, David, Michael, Press, William H., Sawyer, Sara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189954/
https://www.ncbi.nlm.nih.gov/pubmed/28027315
http://dx.doi.org/10.1371/journal.ppat.1006066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189954/
https://www.ncbi.nlm.nih.gov/pubmed/28027315
http://dx.doi.org/10.1371/journal.ppat.1006066

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