The Yes-associated protein controls the cell density regulation of Hedgehog signaling

The evolutionarily conserved Hedgehog (Hh) signaling pathway is essential for correct embryogenesis and is misregulated in several malignancies. In cell culture, Hh-sensitive cells display a striking dependence on cell density with active Hh signaling requiring cell-to-cell contact. As the Hippo/YAP...

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Detalles Bibliográficos
Autores principales: Tariki, M, Dhanyamraju, P K, Fendrich, V, Borggrefe, T, Feldmann, G, Lauth, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5189961/
https://www.ncbi.nlm.nih.gov/pubmed/25111861
http://dx.doi.org/10.1038/oncsis.2014.27

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