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BET bromodomain inhibitors suppress EWS-FLI1-dependent transcription and the IGF1 autocrine mechanism in Ewing sarcoma

Ewing sarcoma is driven by characteristic chromosomal translocations between the EWSR1 gene with genes encoding ETS family transcription factors (EWS-ETS), most commonly FLI1. However, direct pharmacological inhibition of transcription factors like EWS-FLI1 remains largely unsuccessful. Active gene...

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Detalles Bibliográficos
Autores principales:	Loganathan, Sudan N., Tang, Nan, Fleming, Jonathan T., Ma, Yufang, Guo, Yan, Borinstein, Scott C., Chiang, Chin, Wang, Jialiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190040/ https://www.ncbi.nlm.nih.gov/pubmed/27259270 http://dx.doi.org/10.18632/oncotarget.9762

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