Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis

Dedifferentiated chondrosarcoma (DDCS) is a rare disease with a dismal prognosis. DDCS consists of two morphologically distinct components: the cartilaginous and noncartilaginous components. Whether the two components originate from the same progenitor cells has been controversial. Recurrent DDCS co...

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Detalles Bibliográficos
Autores principales: Gao, Lu, Hong, Xiafei, Guo, Xiaopeng, Cao, Dengfeng, Gao, Xiaohuan, DeLaney, Thomas F., Gong, Xinqi, Chen, Rongrong, Ni, Jianjiao, Yao, Yong, Wang, Renzhi, Chen, Xi, Tian, Pangzehuan, Xing, Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190044/
https://www.ncbi.nlm.nih.gov/pubmed/27248819
http://dx.doi.org/10.18632/oncotarget.9618

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