Extracellular vesicles secreted by highly metastatic clonal variants of osteosarcoma preferentially localize to the lungs and induce metastatic behaviour in poorly metastatic clones

Osteosarcoma (OS) is the most common pediatric bone tumor and is associated with the emergence of pulmonary metastasis. Unfortunately, the mechanistic basis for metastasis remains unclear. Tumor-derived extracellular vesicles (EVs) have been shown to play critical roles in cell-to-cell communication...

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Detalles Bibliográficos
Autores principales: Macklin, Rebecca, Wang, Haolu, Loo, Dorothy, Martin, Sally, Cumming, Andrew, Cai, Na, Lane, Rebecca, Ponce, Natalia Saenz, Topkas, Eleni, Inder, Kerry, Saunders, Nicholas A, Endo-Munoz, Liliana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190045/
https://www.ncbi.nlm.nih.gov/pubmed/27259278
http://dx.doi.org/10.18632/oncotarget.9781

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