Missense mutations in the TP53 DNA-binding domain predict outcomes in patients with advanced oral cavity squamous cell carcinoma

TP53 mutations have been linked to reduced survival in patients with oral cavity squamous cell carcinoma (OSCC). However, the impact of different types of TP53 mutations remains unclear. Here, we demonstrate that the carriage of missense mutations in the TP53 DNA binding domain (DBD missense mutatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Lapke, Nina, Lu, Yen-Jung, Liao, Chun-Ta, Lee, Li-Yu, Lin, Chien-Yu, Wang, Hung-Ming, Ng, Shu-Hang, Chen, Shu-Jen, Yen, Tzu-Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190089/
https://www.ncbi.nlm.nih.gov/pubmed/27283772
http://dx.doi.org/10.18632/oncotarget.9925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190089/
https://www.ncbi.nlm.nih.gov/pubmed/27283772
http://dx.doi.org/10.18632/oncotarget.9925

Ejemplares similares