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An overview of long non-coding RNAs in ovarian cancers
As with miRNAs a decade ago, the scientific community recently understood that lncRNAs represent a new layer of complexity in the regulation of gene expression. Although only a subset of lncRNAs has been functionally characterized, it is clear that they are deeply involved in the most critical physi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190131/ https://www.ncbi.nlm.nih.gov/pubmed/26992233 http://dx.doi.org/10.18632/oncotarget.8089 |
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author | Meryet-Figuière, Matthieu Lambert, Bernard Gauduchon, Pascal Vigneron, Nicolas Brotin, Emilie Poulain, Laurent Denoyelle, Christophe |
author_facet | Meryet-Figuière, Matthieu Lambert, Bernard Gauduchon, Pascal Vigneron, Nicolas Brotin, Emilie Poulain, Laurent Denoyelle, Christophe |
author_sort | Meryet-Figuière, Matthieu |
collection | PubMed |
description | As with miRNAs a decade ago, the scientific community recently understood that lncRNAs represent a new layer of complexity in the regulation of gene expression. Although only a subset of lncRNAs has been functionally characterized, it is clear that they are deeply involved in the most critical physiological and pathological biological processes. This review shows that in ovarian carcinoma, data already available testify to the importance of lncRNAs and that the demonstration of an ever-growing role of lncRNAs in the biology of this malignancy can be expected from future studies. We also underline the importance of their relationship with associated protein partners and miRNAs. Together, the available information suggests that the emerging field of lncRNAs will pave the way for a better understanding of ovarian cancer biology and might lead to the development of innovative therapeutic approaches. Moreover, lncRNAs expression signatures either alone or in combination with other types of markers (miRNAs, mRNAs, proteins) could prove useful to predict outcome or treatment follow-up in order to improve the therapeutic care of ovarian carcinoma patients. |
format | Online Article Text |
id | pubmed-5190131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-51901312017-01-05 An overview of long non-coding RNAs in ovarian cancers Meryet-Figuière, Matthieu Lambert, Bernard Gauduchon, Pascal Vigneron, Nicolas Brotin, Emilie Poulain, Laurent Denoyelle, Christophe Oncotarget Review As with miRNAs a decade ago, the scientific community recently understood that lncRNAs represent a new layer of complexity in the regulation of gene expression. Although only a subset of lncRNAs has been functionally characterized, it is clear that they are deeply involved in the most critical physiological and pathological biological processes. This review shows that in ovarian carcinoma, data already available testify to the importance of lncRNAs and that the demonstration of an ever-growing role of lncRNAs in the biology of this malignancy can be expected from future studies. We also underline the importance of their relationship with associated protein partners and miRNAs. Together, the available information suggests that the emerging field of lncRNAs will pave the way for a better understanding of ovarian cancer biology and might lead to the development of innovative therapeutic approaches. Moreover, lncRNAs expression signatures either alone or in combination with other types of markers (miRNAs, mRNAs, proteins) could prove useful to predict outcome or treatment follow-up in order to improve the therapeutic care of ovarian carcinoma patients. Impact Journals LLC 2016-03-15 /pmc/articles/PMC5190131/ /pubmed/26992233 http://dx.doi.org/10.18632/oncotarget.8089 Text en Copyright: © 2016 Meryet-Figuière et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Meryet-Figuière, Matthieu Lambert, Bernard Gauduchon, Pascal Vigneron, Nicolas Brotin, Emilie Poulain, Laurent Denoyelle, Christophe An overview of long non-coding RNAs in ovarian cancers |
title | An overview of long non-coding RNAs in ovarian cancers |
title_full | An overview of long non-coding RNAs in ovarian cancers |
title_fullStr | An overview of long non-coding RNAs in ovarian cancers |
title_full_unstemmed | An overview of long non-coding RNAs in ovarian cancers |
title_short | An overview of long non-coding RNAs in ovarian cancers |
title_sort | overview of long non-coding rnas in ovarian cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190131/ https://www.ncbi.nlm.nih.gov/pubmed/26992233 http://dx.doi.org/10.18632/oncotarget.8089 |
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