How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies

In the last five years, everolimus has demonstrated efficacy in the treatment of neuroendocrine tumors (NETs) of different origins; its efficacy and safety were explored in the RADIANT trials, the last of which (RADIANT-4) has been recently published (December 2015). Overall, evidence collected from...

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Autores principales: Pusceddu, Sara, De Braud, Filippo, Russo, Giuseppe Lo, Concas, Laura, Femia, Daniela, Vernieri, Claudio, Indini, Alice, Formisano, Barbara, Buzzoni, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190138/
https://www.ncbi.nlm.nih.gov/pubmed/27057638
http://dx.doi.org/10.18632/oncotarget.8601
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author Pusceddu, Sara
De Braud, Filippo
Russo, Giuseppe Lo
Concas, Laura
Femia, Daniela
Vernieri, Claudio
Indini, Alice
Formisano, Barbara
Buzzoni, Roberto
author_facet Pusceddu, Sara
De Braud, Filippo
Russo, Giuseppe Lo
Concas, Laura
Femia, Daniela
Vernieri, Claudio
Indini, Alice
Formisano, Barbara
Buzzoni, Roberto
author_sort Pusceddu, Sara
collection PubMed
description In the last five years, everolimus has demonstrated efficacy in the treatment of neuroendocrine tumors (NETs) of different origins; its efficacy and safety were explored in the RADIANT trials, the last of which (RADIANT-4) has been recently published (December 2015). Overall, evidence collected from the RADIANT studies holds promise to change clinical practice for the treatment of NETs. In this paper, we comment on the role of everolimus within the therapeutic algorithm for NETs treatment, based on the systematic analysis of the RADIANT trials and our experience.
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spelling pubmed-51901382017-01-05 How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies Pusceddu, Sara De Braud, Filippo Russo, Giuseppe Lo Concas, Laura Femia, Daniela Vernieri, Claudio Indini, Alice Formisano, Barbara Buzzoni, Roberto Oncotarget Review In the last five years, everolimus has demonstrated efficacy in the treatment of neuroendocrine tumors (NETs) of different origins; its efficacy and safety were explored in the RADIANT trials, the last of which (RADIANT-4) has been recently published (December 2015). Overall, evidence collected from the RADIANT studies holds promise to change clinical practice for the treatment of NETs. In this paper, we comment on the role of everolimus within the therapeutic algorithm for NETs treatment, based on the systematic analysis of the RADIANT trials and our experience. Impact Journals LLC 2016-04-05 /pmc/articles/PMC5190138/ /pubmed/27057638 http://dx.doi.org/10.18632/oncotarget.8601 Text en Copyright: © 2016 Pusceddu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Pusceddu, Sara
De Braud, Filippo
Russo, Giuseppe Lo
Concas, Laura
Femia, Daniela
Vernieri, Claudio
Indini, Alice
Formisano, Barbara
Buzzoni, Roberto
How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies
title How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies
title_full How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies
title_fullStr How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies
title_full_unstemmed How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies
title_short How do the results of the RADIANT trials impact on the management of NET patients? A systematic review of published studies
title_sort how do the results of the radiant trials impact on the management of net patients? a systematic review of published studies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5190138/
https://www.ncbi.nlm.nih.gov/pubmed/27057638
http://dx.doi.org/10.18632/oncotarget.8601
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