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One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing

We build on the concept of hot intrusion embossing to develop a one-step fabrication method for thermoplastic microfluidic channels containing integrated three-dimensional features. This was accomplished with simple, rapid-to-fabricate imprint templates containing microcavities that locally control...

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Detalles Bibliográficos
Autores principales: Debono, Mike, Voicu, Dan, Pousti, Mohammad, Safdar, Muhammad, Young, Robert, Kumacheva, Eugenia, Greener, Jesse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191004/
https://www.ncbi.nlm.nih.gov/pubmed/27916849
http://dx.doi.org/10.3390/s16122023
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author Debono, Mike
Voicu, Dan
Pousti, Mohammad
Safdar, Muhammad
Young, Robert
Kumacheva, Eugenia
Greener, Jesse
author_facet Debono, Mike
Voicu, Dan
Pousti, Mohammad
Safdar, Muhammad
Young, Robert
Kumacheva, Eugenia
Greener, Jesse
author_sort Debono, Mike
collection PubMed
description We build on the concept of hot intrusion embossing to develop a one-step fabrication method for thermoplastic microfluidic channels containing integrated three-dimensional features. This was accomplished with simple, rapid-to-fabricate imprint templates containing microcavities that locally control the intrusion of heated thermoplastic based on their cross-sectional geometries. The use of circular, rectangular and triangular cavity geometries was demonstrated for the purposes of forming posts, multi-focal length microlense arrays, walls, steps, tapered features and three-dimensional serpentine microchannels. Process variables, such as temperature and pressure, controlled feature dimensions without affecting the overall microchannel geometry. The approach was demonstrated for polycarbonate, cycloolefin copolymer and polystyrene, but in principle is applicable to any thermoplastic. The approach is a step forward towards rapid fabrication of complex, robust, microfluidic platforms with integrated multi-functional elements.
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spelling pubmed-51910042017-01-03 One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing Debono, Mike Voicu, Dan Pousti, Mohammad Safdar, Muhammad Young, Robert Kumacheva, Eugenia Greener, Jesse Sensors (Basel) Article We build on the concept of hot intrusion embossing to develop a one-step fabrication method for thermoplastic microfluidic channels containing integrated three-dimensional features. This was accomplished with simple, rapid-to-fabricate imprint templates containing microcavities that locally control the intrusion of heated thermoplastic based on their cross-sectional geometries. The use of circular, rectangular and triangular cavity geometries was demonstrated for the purposes of forming posts, multi-focal length microlense arrays, walls, steps, tapered features and three-dimensional serpentine microchannels. Process variables, such as temperature and pressure, controlled feature dimensions without affecting the overall microchannel geometry. The approach was demonstrated for polycarbonate, cycloolefin copolymer and polystyrene, but in principle is applicable to any thermoplastic. The approach is a step forward towards rapid fabrication of complex, robust, microfluidic platforms with integrated multi-functional elements. MDPI 2016-11-29 /pmc/articles/PMC5191004/ /pubmed/27916849 http://dx.doi.org/10.3390/s16122023 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Debono, Mike
Voicu, Dan
Pousti, Mohammad
Safdar, Muhammad
Young, Robert
Kumacheva, Eugenia
Greener, Jesse
One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing
title One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing
title_full One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing
title_fullStr One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing
title_full_unstemmed One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing
title_short One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing
title_sort one-step fabrication of microchannels with integrated three dimensional features by hot intrusion embossing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191004/
https://www.ncbi.nlm.nih.gov/pubmed/27916849
http://dx.doi.org/10.3390/s16122023
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