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One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing
We build on the concept of hot intrusion embossing to develop a one-step fabrication method for thermoplastic microfluidic channels containing integrated three-dimensional features. This was accomplished with simple, rapid-to-fabricate imprint templates containing microcavities that locally control...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191004/ https://www.ncbi.nlm.nih.gov/pubmed/27916849 http://dx.doi.org/10.3390/s16122023 |
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author | Debono, Mike Voicu, Dan Pousti, Mohammad Safdar, Muhammad Young, Robert Kumacheva, Eugenia Greener, Jesse |
author_facet | Debono, Mike Voicu, Dan Pousti, Mohammad Safdar, Muhammad Young, Robert Kumacheva, Eugenia Greener, Jesse |
author_sort | Debono, Mike |
collection | PubMed |
description | We build on the concept of hot intrusion embossing to develop a one-step fabrication method for thermoplastic microfluidic channels containing integrated three-dimensional features. This was accomplished with simple, rapid-to-fabricate imprint templates containing microcavities that locally control the intrusion of heated thermoplastic based on their cross-sectional geometries. The use of circular, rectangular and triangular cavity geometries was demonstrated for the purposes of forming posts, multi-focal length microlense arrays, walls, steps, tapered features and three-dimensional serpentine microchannels. Process variables, such as temperature and pressure, controlled feature dimensions without affecting the overall microchannel geometry. The approach was demonstrated for polycarbonate, cycloolefin copolymer and polystyrene, but in principle is applicable to any thermoplastic. The approach is a step forward towards rapid fabrication of complex, robust, microfluidic platforms with integrated multi-functional elements. |
format | Online Article Text |
id | pubmed-5191004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-51910042017-01-03 One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing Debono, Mike Voicu, Dan Pousti, Mohammad Safdar, Muhammad Young, Robert Kumacheva, Eugenia Greener, Jesse Sensors (Basel) Article We build on the concept of hot intrusion embossing to develop a one-step fabrication method for thermoplastic microfluidic channels containing integrated three-dimensional features. This was accomplished with simple, rapid-to-fabricate imprint templates containing microcavities that locally control the intrusion of heated thermoplastic based on their cross-sectional geometries. The use of circular, rectangular and triangular cavity geometries was demonstrated for the purposes of forming posts, multi-focal length microlense arrays, walls, steps, tapered features and three-dimensional serpentine microchannels. Process variables, such as temperature and pressure, controlled feature dimensions without affecting the overall microchannel geometry. The approach was demonstrated for polycarbonate, cycloolefin copolymer and polystyrene, but in principle is applicable to any thermoplastic. The approach is a step forward towards rapid fabrication of complex, robust, microfluidic platforms with integrated multi-functional elements. MDPI 2016-11-29 /pmc/articles/PMC5191004/ /pubmed/27916849 http://dx.doi.org/10.3390/s16122023 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Debono, Mike Voicu, Dan Pousti, Mohammad Safdar, Muhammad Young, Robert Kumacheva, Eugenia Greener, Jesse One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing |
title | One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing |
title_full | One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing |
title_fullStr | One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing |
title_full_unstemmed | One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing |
title_short | One-Step Fabrication of Microchannels with Integrated Three Dimensional Features by Hot Intrusion Embossing |
title_sort | one-step fabrication of microchannels with integrated three dimensional features by hot intrusion embossing |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191004/ https://www.ncbi.nlm.nih.gov/pubmed/27916849 http://dx.doi.org/10.3390/s16122023 |
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