Cargando…

Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate

This paper proposes a neural stimulation device integrated with a silicon nanowire (SiNW)-based photodetection circuit for the activation of neurons with light. The proposed device is comprised of a voltage divider and a current driver in which SiNWs are used as photodetector and field-effect transi...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Suk Won, Shin, Jong Yoon, Pi, Kilwha, Goo, Yong Sook, Cho, Dong-il “Dan”
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191016/
https://www.ncbi.nlm.nih.gov/pubmed/27916963
http://dx.doi.org/10.3390/s16122035
_version_ 1782487536533241856
author Jung, Suk Won
Shin, Jong Yoon
Pi, Kilwha
Goo, Yong Sook
Cho, Dong-il “Dan”
author_facet Jung, Suk Won
Shin, Jong Yoon
Pi, Kilwha
Goo, Yong Sook
Cho, Dong-il “Dan”
author_sort Jung, Suk Won
collection PubMed
description This paper proposes a neural stimulation device integrated with a silicon nanowire (SiNW)-based photodetection circuit for the activation of neurons with light. The proposed device is comprised of a voltage divider and a current driver in which SiNWs are used as photodetector and field-effect transistors; it has the functions of detecting light, generating a stimulation signal in proportion to the light intensity, and transmitting the signal to a micro electrode. To show the applicability of the proposed neural stimulation device as a high-resolution retinal prosthesis system, a high-density neural stimulation device with a unit cell size of [Formula: see text] and a resolution of [Formula: see text] was fabricated on a flexible film with a thickness of approximately 50 μm. Its effectiveness as a retinal stimulation device was then evaluated using a unit cell in an in vitro animal experiment involving the retinal tissue of retinal Degeneration 1 (rd1) mice. Experiments wherein stimulation pulses were applied to the retinal tissues successfully demonstrate that the number of spikes in neural response signals increases in proportion to light intensity.
format Online
Article
Text
id pubmed-5191016
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-51910162017-01-03 Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate Jung, Suk Won Shin, Jong Yoon Pi, Kilwha Goo, Yong Sook Cho, Dong-il “Dan” Sensors (Basel) Article This paper proposes a neural stimulation device integrated with a silicon nanowire (SiNW)-based photodetection circuit for the activation of neurons with light. The proposed device is comprised of a voltage divider and a current driver in which SiNWs are used as photodetector and field-effect transistors; it has the functions of detecting light, generating a stimulation signal in proportion to the light intensity, and transmitting the signal to a micro electrode. To show the applicability of the proposed neural stimulation device as a high-resolution retinal prosthesis system, a high-density neural stimulation device with a unit cell size of [Formula: see text] and a resolution of [Formula: see text] was fabricated on a flexible film with a thickness of approximately 50 μm. Its effectiveness as a retinal stimulation device was then evaluated using a unit cell in an in vitro animal experiment involving the retinal tissue of retinal Degeneration 1 (rd1) mice. Experiments wherein stimulation pulses were applied to the retinal tissues successfully demonstrate that the number of spikes in neural response signals increases in proportion to light intensity. MDPI 2016-12-01 /pmc/articles/PMC5191016/ /pubmed/27916963 http://dx.doi.org/10.3390/s16122035 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jung, Suk Won
Shin, Jong Yoon
Pi, Kilwha
Goo, Yong Sook
Cho, Dong-il “Dan”
Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate
title Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate
title_full Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate
title_fullStr Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate
title_full_unstemmed Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate
title_short Neuron Stimulation Device Integrated with Silicon Nanowire-Based Photodetection Circuit on a Flexible Substrate
title_sort neuron stimulation device integrated with silicon nanowire-based photodetection circuit on a flexible substrate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191016/
https://www.ncbi.nlm.nih.gov/pubmed/27916963
http://dx.doi.org/10.3390/s16122035
work_keys_str_mv AT jungsukwon neuronstimulationdeviceintegratedwithsiliconnanowirebasedphotodetectioncircuitonaflexiblesubstrate
AT shinjongyoon neuronstimulationdeviceintegratedwithsiliconnanowirebasedphotodetectioncircuitonaflexiblesubstrate
AT pikilwha neuronstimulationdeviceintegratedwithsiliconnanowirebasedphotodetectioncircuitonaflexiblesubstrate
AT gooyongsook neuronstimulationdeviceintegratedwithsiliconnanowirebasedphotodetectioncircuitonaflexiblesubstrate
AT chodongildan neuronstimulationdeviceintegratedwithsiliconnanowirebasedphotodetectioncircuitonaflexiblesubstrate