Cargando…
Postoperative opioid sparing with injectable hydroxypropyl-β-cyclodextrin-diclofenac: pooled analysis of data from two Phase III clinical trials
PURPOSE: Use of nonopioid analgesics (including nonsteroidal anti-inflammatory drugs) for postoperative pain management can reduce opioid consumption and potentially prevent opioid-related adverse events. This study examined the postoperative opioid-sparing effect of repeated-dose injectable diclofe...
Autores principales: | Gan, Tong J, Singla, Neil, Daniels, Stephen E, Hamilton, Douglas A, Lacouture, Peter G, Reyes, Christian RD, Carr, Daniel B |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191619/ https://www.ncbi.nlm.nih.gov/pubmed/28053554 http://dx.doi.org/10.2147/JPR.S106578 |
Ejemplares similares
-
A Phase I study evaluating the effect of age and weight on the pharmacokinetics of an injectable formulation of diclofenac solubilized with hydroxypropyl-β-cyclodextrin
por: Goldwater, Ronald, et al.
Publicado: (2016) -
Pharmacokinetics of Diclofenac and Hydroxypropyl‐β‐Cyclodextrin (HPβCD) Following Administration of Injectable HPβCD‐Diclofenac in Subjects With Mild to Moderate Renal Insufficiency or Mild Hepatic Impairment
por: Hamilton, Douglas A., et al.
Publicado: (2017) -
Safety of Injectable HPβCD-Diclofenac in Older Patients with Acute Moderate-to-Severe Postoperative Pain: A Pooled Analysis of Three Phase III Trials
por: Chelly, Jacques E., et al.
Publicado: (2018) -
Effect of 2-Hydroxypropyl-β-cyclodextrin on Solubility of Sparingly Soluble Drug Derivatives of Anthranilic Acid
por: Domańska, Urszula, et al.
Publicado: (2011) -
Encapsulation Mechanism of Oxyresveratrol by β-Cyclodextrin and Hydroxypropyl-β-Cyclodextrin and Computational Analysis
por: He, Jianfei, et al.
Publicado: (2017)