Single-Cell-Based Analysis Highlights a Surge in Cell-to-Cell Molecular Variability Preceding Irreversible Commitment in a Differentiation Process

In some recent studies, a view emerged that stochastic dynamics governing the switching of cells from one differentiation state to another could be characterized by a peak in gene expression variability at the point of fate commitment. We have tested this hypothesis at the single-cell level by analy...

Descripción completa

Detalles Bibliográficos
Autores principales: Richard, Angélique, Boullu, Loïs, Herbach, Ulysse, Bonnafoux, Arnaud, Morin, Valérie, Vallin, Elodie, Guillemin, Anissa, Papili Gao, Nan, Gunawan, Rudiyanto, Cosette, Jérémie, Arnaud, Ophélie, Kupiec, Jean-Jacques, Espinasse, Thibault, Gonin-Giraud, Sandrine, Gandrillon, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191835/
https://www.ncbi.nlm.nih.gov/pubmed/28027290
http://dx.doi.org/10.1371/journal.pbio.1002585

Ejemplares similares

Ejemplares similares