Aging is associated with an expansion of CD49f(hi) mammary stem cells that show a decline in function and increased transformation potential

Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated f...

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Detalles Bibliográficos
Autores principales: Dong, Qiaoxiang, Gao, Hui, Shi, Yuanshuo, Zhang, Fuchuang, Gu, Xiang, Wu, Anqi, Wang, Danhan, Chen, Yuanhong, Bandyopadhyay, Abhik, Yeh, I-Tien, Daniel, Benjamin J., Chen, Yidong, Zou, Yi, Rebel, Vivienne L., Walter, Christi A., Lu, Jianxin, Huang, Changjiang, Sun, Lu-Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191868/
https://www.ncbi.nlm.nih.gov/pubmed/27852980
http://dx.doi.org/10.18632/aging.101082

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