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Long-term caloric restriction in ApoE-deficient mice results in neuroprotection via Fgf21-induced AMPK/mTOR pathway

Caloric restriction (CR) decelerates the aging process, extends lifespan and exerts neuroprotective effects in diverse species by so far unknown mechanisms. Based on known neuroprotective effects of fibroblastic growth factor 21 (Fgf21) we speculate that CR upregulates Fgf21, which phosphorylates ne...

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Detalles Bibliográficos
Autores principales:	Rühlmann, Claire, Wölk, Tjark, Blümel, Tobias, Stahn, Laura, Vollmar, Brigitte, Kuhla, Angela
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5191869/ https://www.ncbi.nlm.nih.gov/pubmed/27902456 http://dx.doi.org/10.18632/aging.101086

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